Barnett M L, Press K P, Friedman D, Sonnenberg E M
J Periodontol. 1986 May;57(5):288-93. doi: 10.1902/jop.1986.57.5.288.
The prevalence rates of periodontitis and dental caries in 30 Down's syndrome patients and 30 matched, otherwise retarded, controls were compared. The populations were older than those usually studied, with mean (+/- SE) ages of 27.4 (+/- 2.1) and 28.9 (+/- 2.3) for the Down's syndrome and control groups, respectively. Bone loss was found in 60.0% of sites in the Down's syndrome patients, compared with 9.3% sites in controls. In Down's syndrome, bone loss was first seen at about age 16, with 92% of patients 16 or older having loss; in contrast, only 42% of control patients 16 or older had bone loss, which first appeared at about age 28. There was a considerable difference in caries prevalence in the two groups, with the Down's syndrome patients having a lower overall prevalence which was most noticeable with respect to interproximal lesions. Seven Down's syndrome patients over age 15 were caries-free, as opposed to only one control patient.
比较了30名唐氏综合征患者和30名匹配的、其他方面智力迟钝的对照组患者的牙周炎和龋齿患病率。这些人群的年龄比通常研究的人群更大，唐氏综合征组和对照组的平均（±标准误）年龄分别为27.4（±2.1）岁和28.9（±2.3）岁。唐氏综合征患者60.0%的部位出现骨质流失，而对照组为9.3%。在唐氏综合征中，骨质流失在大约16岁时首次出现，16岁及以上患者中有92%出现骨质流失；相比之下，16岁及以上的对照患者中只有42%出现骨质流失，骨质流失首次出现在大约28岁。两组的龋齿患病率有相当大的差异，唐氏综合征患者的总体患病率较低，这在邻面病变方面最为明显。15岁以上的7名唐氏综合征患者无龋齿，而对照组只有1名患者无龋齿。
