Rajamannan Nalini M
Division of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, and Most Sacred Heart of Jesus Cardiology and Valvular Institute, Sheboygan, WI, USA.
Cardiology. 2018;139(3):175-183. doi: 10.1159/000485074. Epub 2018 Jan 27.
Recent epidemiological studies have revealed that the risk factors associated with coronary artery calcification (CAC), including male gender, smoking, hypertension, and elevated serum cholesterol, are similar to the risk factors associated with the development of calcific aortic valve disease (CAVD). The results of the experimental and clinical studies demonstrate that traditional risk factors initiate early atherosclerosis which over time differentiates to form bone in the heart causing clinical CAC and CAVD. Understanding the cellular mechanisms of cardiovascular calcification, the end-stage process of the atherosclerosis will help define the specific time point to modify this cellular process of bone formation in the heart termed osteocardiology. This time point between subclinical atherosclerosis and clinical calcification is the go/no-go time point, or the point of no return with severe clinical calcification in the heart. This review will summarize the development of bone formation in the heart termed osteocardiology, to define the go/no-go time point for therapy initiation to slow the progression of cardiovascular calcification.
近期的流行病学研究表明，与冠状动脉钙化（CAC）相关的危险因素，包括男性、吸烟、高血压和血清胆固醇升高，与钙化性主动脉瓣疾病（CAVD）发展的危险因素相似。实验和临床研究结果表明，传统危险因素引发早期动脉粥样硬化，随着时间推移，其会分化形成心脏中的骨组织，导致临床CAC和CAVD。了解心血管钙化这一动脉粥样硬化终末期过程的细胞机制，将有助于确定特定时间点，以改变心脏中这种称为骨心学的骨形成细胞过程。亚临床动脉粥样硬化与临床钙化之间的这个时间点是决定是否采取行动的时间点，即心脏出现严重临床钙化后不可逆转的时间点。本综述将总结心脏中称为骨心学的骨形成发展过程，以确定开始治疗以减缓心血管钙化进展的决定是否采取行动的时间点。
