Dijon Stroke Registry, EA7460, Pathophysiology and Epidemiology of Cerebro-Cardiovascular Diseases (PEC2), University Hospital of Dijon, University of Burgundy, Dijon, France.
Department of Neurology, Centre Hospitalier William Morey, Chalon-sur-Saône, France.
Neuroepidemiology. 2018;50(1-2):47-56. doi: 10.1159/000486397. Epub 2018 Feb 1.
We aimed to provide a representation of the global burden of stroke.
All cases of stroke were prospectively identified through the population-based registry of Dijon, France (1987-2012). Attack rates and mortality rates (defined as stroke leading to death within 30 days) were standardized to the European standard. Sex differences and temporal trends were evaluated by calculating rate ratios (RRs).
In all, 5,285 stroke cases (52.7% women) were recorded. The standardized attack rate was 98.2/100,000/year and the mortality rate was 12/100,000/year, and both were lower in women than in men (RR 0.67, p < 0.001, and RR 0.70, p < 0.001, respectively). Attack rates increased over time (RR 1.016; 95% CI 1.013-1.020) irrespective of the stroke subtype. In contrast, mortality rates declined (RR 0.985; 95% CI 0.976-0.995) with decreasing rates for ischemic stroke but no change for intracerebral hemorrhage and subarachnoid hemorrhage. The sex gap in both attack and mortality rates remained stable. Between the first (1987-1991) and the last (2007-2012) study periods, the annual number of stroke patients who survived beyond 30 days rose by 55%, Conclusions: Increasing attack rates and decreasing mortality have led to a rise in the number of stroke survivors in the population, thus indicating a growing need for the implementation of dedicated services.
我们旨在提供全球卒中负担的代表性描述。
所有卒中病例均通过法国第戎的基于人群的登记处前瞻性识别（1987-2012 年）。发病率和死亡率（定义为 30 天内卒中导致的死亡）按欧洲标准标准化。通过计算率比（RR）评估性别差异和时间趋势。
共记录了 5285 例卒中病例（52.7%为女性）。标准化发病率为 98.2/100,000/年，死亡率为 12/100,000/年，女性均低于男性（RR 0.67，p<0.001 和 RR 0.70，p<0.001）。发病率随时间增加（RR 1.016；95%CI 1.013-1.020），无论卒中亚型如何。相反，死亡率下降（RR 0.985；95%CI 0.976-0.995），缺血性卒中和蛛网膜下腔出血的死亡率下降，而脑出血的死亡率没有变化。发病率和死亡率的性别差距保持稳定。在第一个研究期间（1987-1991 年）和最后一个研究期间（2007-2012 年）之间，30 天后存活的卒中患者人数每年增加 55%。
发病率的增加和死亡率的降低导致人群中卒中幸存者的数量增加，这表明需要实施专门的服务。
