Schatzschneider Ulrich
Met Ions Life Sci. 2018 Feb 5;18. doi: 10.1515/9783110470734-020.
As the carrier of the inheritable information in cells, DNA has been the target of metal complexes for over 40 years. In this chapter, the focus will be on non-covalent recognition of the highly structured DNA surface by substitutionally inert metal complexes capable of either sliding in between the normal base pairs as metallointercalators or flipping out thermodynamically destabilized mispaired nucleobases as metalloinsertors. While most of the compounds discussed are based on ruthenium(II) and rhodium(III) due to their stable octahedral coordination environment and low-spin 4d6 electronic configuration, most recent developments of alternative metal complexes, based on both transition metals and main group elements, will also be highlighted. A particular focus of the coverage is on structural data from X-ray structure analysis, which now provides details of the interaction at unprecedented details and will enable development of novel DNA binding probes for fundamental studies as well as new anticancer drug candidates.
作为细胞中可遗传信息的载体，DNA在过去40多年里一直是金属配合物的作用靶点。在本章中，重点将是取代惰性金属配合物对高度结构化DNA表面的非共价识别，这些配合物能够作为金属嵌入剂在正常碱基对之间滑动，或者作为金属插入剂翻转出热力学不稳定的错配核碱基。虽然所讨论的大多数化合物基于钌（II）和铑（III），这是由于它们具有稳定的八面体配位环境和低自旋4d6电子构型，但基于过渡金属和主族元素的替代金属配合物的最新进展也将得到突出介绍。报道的一个特别重点是来自X射线结构分析的结构数据，现在这些数据以前所未有的细节提供了相互作用的详情，并将有助于开发用于基础研究的新型DNA结合探针以及新的抗癌候选药物。
