Soma Daiki, Sakata Jun, Ando Takuya, Yuza Kizuki, Ishikawa Hirosuke, Ohashi Taku, Takizawa Kazuyasu, Takano Kabuto, Kobayashi Takashi, Ichikawa Hiroshi, Hanyu Takaaki, Nagahashi Masayuki, Shimada Yoshifumi, Kameyama Hitoshi, Wakai Toshifumi
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.
Gan To Kagaku Ryoho. 2017 Nov;44(12):1565-1567.
Lymph node metastasis has a poor prognosis in patients with hepatocellular carcinoma(HCC). We report a case of HCC with lymph node metastasis successfully treated by multidisciplinary treatment. An 81-year-old woman who was followed up for liver cirrhosis received a diagnosis of HCC, which was detected by CT as a solitary tumor 20mm in diameter in the couinaud segment 7 of the liver. She underwent transcatheter arterial chemoembolization(TACE)twice for HCC because of her advanced age and no intention to undergo hepatectomy. Some 12 months later, local recurrence was managed by repeat TACE and paraaortic lymph node metastasis by surgical resection. The patient received radiotherapy for mediastinal nodal disease 6 months after the resection. She remains alive and well without no evidence of disease 84 months after the initial treatment. This case and a review of the literature suggest that multidisciplinary treatment with TACE, surgical resection and radiotherapy may provide a survival benefit for selected patients with HCC with isolated lymph node metastasis.
淋巴结转移在肝细胞癌(HCC)患者中预后较差。我们报告一例通过多学科治疗成功治疗的伴有淋巴结转移的HCC病例。一名因肝硬化接受随访的81岁女性被诊断为HCC,CT检查发现肝脏Couinaud 7段有一个直径20mm的孤立肿瘤。由于她年龄较大且无意接受肝切除术,因此因HCC接受了两次经动脉化疗栓塞术(TACE)。大约12个月后,通过重复TACE处理局部复发,并通过手术切除处理主动脉旁淋巴结转移。患者在切除术后6个月接受了纵隔淋巴结疾病的放疗。初始治疗84个月后,她仍然存活且状况良好,无疾病证据。该病例及文献综述表明,TACE、手术切除和放疗的多学科治疗可能为选定的孤立性淋巴结转移的HCC患者提供生存益处。