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经动脉化疗栓塞及经皮局部治疗后腹腔镜切除肝细胞癌孤立性淋巴结转移灶

[Laparoscopic Resection of Solitary Lymph Node Metastasis of Hepatocellular Carcinoma after Transcatheter Arterial Chemoembolization and Percutaneous Locoregional Therapies].

作者信息

Tsukamoto Tadashi, Kodai Shintaro, Yamamoto Satoshi, Yamazoe Sadaaki, Kanazawa Akishige, Nishiyama Tsuyoshi, Nobori Chihoko, Kunimoto Tomohiro, Kaizaki Ryoji, Inoue Toru, Nishiguchi Yukio

机构信息

Dept. of Surgery, Osaka City Juso Hospital.

出版信息

Gan To Kagaku Ryoho. 2020 Dec;47(13):1896-1898.

Abstract

A 75-year-old woman underwent transcatheter chemoembolization(TACE)for 2 small hepatocellular carcinoma(HCC) lesions associated with severe alcoholic liver cirrhosis that necessitated management for ascites. Over 5 years after the initial TACE, she received multidisciplinary therapies with TACE, transcatheter arterial infusion of anticancer agents, percutaneous ethanol injections, or percutaneous radiofrequency ablation performed on 5 occasions for small recurrent HCC lesions. Computed tomography performed after the last therapy for HCC revealed a solitary lymph node swelling(39 mm in diameter) around the common hepatic artery. Magnetic resonance imaging performed 3 months later revealed that the lymph node had enlarged to 45 mm, without recurrence of the primary HCC, and after 4 months, to 60 mm; she then underwent laparoscopic lymph node resection. Histopathological examination of the resected specimen showed HCC metastasis. A recurrent metastatic lymph node(30 mm in diameter)was detected around the common hepatic artery and was resected laparoscopically 17 months postoperatively. Pancreatic head cancer was diagnosed 22 months after the second surgery; however, the patient refused cancer therapy and died 16 months after this diagnosis. No recurrence of the primary HCC or lymph node metastasis was observed over the 38 months after the second surgery.

摘要

一名75岁女性因2个小肝细胞癌(HCC)病灶接受经导管化疗栓塞术(TACE),该患者伴有严重酒精性肝硬化且需要对腹水进行处理。在初次TACE术后5年多的时间里,她因小的复发性HCC病灶接受了5次包括TACE、经导管动脉灌注抗癌药物、经皮乙醇注射或经皮射频消融的多学科治疗。对HCC进行最后一次治疗后进行的计算机断层扫描显示肝总动脉周围有一个孤立的淋巴结肿大(直径39毫米)。3个月后进行的磁共振成像显示该淋巴结已增大至45毫米,原发性HCC未复发,4个月后增大至60毫米;随后她接受了腹腔镜淋巴结切除术。切除标本的组织病理学检查显示为HCC转移。术后17个月,在肝总动脉周围检测到一个复发性转移淋巴结(直径30毫米),并通过腹腔镜将其切除。第二次手术后22个月诊断出胰头癌;然而,患者拒绝癌症治疗,在诊断后16个月死亡。第二次手术后38个月内未观察到原发性HCC复发或淋巴结转移。

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