针对骨髓移植对94个丹麦连续家庭的免疫遗传学组成进行了调查。
Immunogenetic composition of 94 consecutive Danish families investigated with respect to bone marrow transplantation.
作者信息
Christiansen S E, Jørgensen F, Kristensen T, Lamm L U, Hansen P W, Kissmeyer-Nielsen F
出版信息
Tokai J Exp Clin Med. 1985 Jun;10(2-3):239-44.
The immunogenetic composition of 94 patients needing bone marrow transplantation and their core families primarily investigated to select family bone marrow donors have been further analysed to test for association between disease and HLA-region markers. From this material it is shown, that in the primary immunogenetic analysis of the family, inclusion of mixed lymphocyte culture analysis increases donor possibilities by approximately 14% when a reciprocal negative MLC response and phenotypic HLA-DR compatibility are accepted as criteria for transplantation. Further, the results indicate, that no association between HLA and leukemia seems to exist.
对94名需要进行骨髓移植的患者及其核心家庭的免疫遗传组成进行了初步调查，以选择家庭骨髓供者，并进一步分析以检测疾病与HLA区域标记之间的关联。从这些资料可以看出，在对家庭进行的初步免疫遗传分析中，当将相互阴性的混合淋巴细胞培养反应和表型HLA-DR相容性作为移植标准时，纳入混合淋巴细胞培养分析可使供者选择的可能性增加约14%。此外，结果表明，HLA与白血病之间似乎不存在关联。
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