HDAC5 调控药物记忆的形成。

HDAC5 Regulates the Formation of Drug Memories.

机构信息

Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.

出版信息

Trends Mol Med. 2018 Feb;24(2):106-108. doi: 10.1016/j.molmed.2017.12.011. Epub 2018 Jan 25.

DOI:10.1016/j.molmed.2017.12.011

PMID:29396145

Abstract

Cocaine-associated environmental cues can precipitate craving and relapse in addicted individuals even after years of abstinence, but the molecular mechanisms by which maladaptive drug memories are generated remain unclear. New findings suggest that histone deacetylase 5 (HDAC5) plays a key role in this process.

摘要

可卡因相关的环境线索即使在戒断多年后也能促使成瘾个体产生觅药渴求并导致复吸，但导致适应不良的药物记忆形成的分子机制仍不清楚。新的研究结果表明，组蛋白去乙酰化酶 5（HDAC5）在这一过程中发挥着关键作用。