Kniep B, Mühlradt P F
Z Naturforsch C J Biosci. 1986 Jan-Feb;41(1-2):100-2.
Neutral glycosphingolipids of human myeloid leukemia cells in different differentiation stages from nine patients were analyzed by high performance liquid chromatography. All cells contained ceramide monohexoside, lactosylceramide and neutral glycosphingolipids of the lacto-series. However, some of the leukemic cells contained neutral glycosphingolipids of the globo-series. Especially myelomonocytic cells (French-American-British or FAB classification M4) and poorly differentiated cells (FAB M0 and M1) were found to contain globo glycosphingolipids. On myeloblast cells, (FAB M2), globo glycosphingolipids were missing or present only in very low amounts. It seemed, therefore, that on myeloid leukemic cells the glycosphingolipid composition may be dependent on their differentiation stage.
采用高效液相色谱法分析了9例处于不同分化阶段的人髓系白血病细胞的中性糖鞘脂。所有细胞均含有神经酰胺单己糖苷、乳糖基神经酰胺和乳糖系列的中性糖鞘脂。然而，一些白血病细胞含有球系列的中性糖鞘脂。特别是发现粒单核细胞（法美英或FAB分类M4）和低分化细胞（FAB M0和M1）含有球糖鞘脂。在原始粒细胞（FAB M2）上，球糖鞘脂缺失或仅以极低的量存在。因此，似乎在髓系白血病细胞上，糖鞘脂的组成可能取决于它们的分化阶段。
