Al-Mahmood H A, el-Khatim M S, Gumaa K A, Thulesius O
Acta Physiol Scand. 1986 Feb;126(2):295-8. doi: 10.1111/j.1748-1716.1986.tb07817.x.
The effect of the calcium-blockers nicardipine, darodipine, PN-200-110 on insulin release from pancreatic islets was studied using nifedipine as a reference compound. All drugs at a concentration of 10(-6)M significantly inhibited insulin release in response to both low (5.5 mM) and high (22 mM) glucose. The present observations support previous reports that calcium blockers of the dihydropyridine series are effective inhibitors of glucose-induced insulin release.
以硝苯地平作为参比化合物，研究了钙通道阻滞剂尼卡地平、达罗地平、PN - 200 - 110对胰岛胰岛素释放的影响。所有浓度为10(-6)M的药物均能显著抑制对低（5.5 mM）、高（22 mM）葡萄糖刺激的胰岛素释放。本研究结果支持此前的报道，即二氢吡啶类钙通道阻滞剂是葡萄糖诱导胰岛素释放的有效抑制剂。
