2007 年多哥脑膜炎奈瑟菌 X 群流行后针对荚膜群 X 型脑膜炎奈瑟氏菌的自然免疫。
Natural immunity against capsular group X N. meningitidis following an outbreak in Togo, 2007.
机构信息
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, and the NIHR Oxford Biomedical Research Centre, Oxford, UK; Norwegian Institute of Public Health, Oslo, Norway.
Agence de Médecine Préventive, Paris, France; Ecole des Hautes Etudes en Santé Publique, Rennes/Paris, France and Institut Pasteur, Paris, France.
出版信息
Vaccine. 2018 Feb 28;36(10):1297-1303. doi: 10.1016/j.vaccine.2018.01.031. Epub 2018 Feb 2.
BACKGROUND
Capsular group X N. meningitidis (MenX) has emerged as a cause of localized disease outbreaks in sub-Saharan Africa, but the human immune response following exposure to MenX antigens is poorly described. We therefore assessed the natural immunity against MenX in individuals who were living in an area affected by a MenX outbreak during 2007 in Togo, West Africa. During 2009, 300 healthy individuals (100 aged 3-5 years, 100 aged 13-19 years and 100 aged 20-25 years) were included in the study, and serum responses were compared with sera from age-matched controls from the U.K. and Burkina Faso.
METHODS
MenX serum bactericidal antibody (SBA) was measured using rabbit complement, and antibodies against MenX polysaccharide (XPS) and outer membrane vesicles (XOMVs) were quantified by ELISA.
RESULTS
The proportion of Togolese individuals with an SBA titer of ≥8 against the MenX strain was 29% (95% confidence interval (CI) 18-41) among those aged 3-5 years, 34% (95% CI 9-60) among those aged 13-19 years and 32% (95% CI 24-40) among those aged 20-25 years. These were significantly higher than observed in the control populations from the U.K (range 13-16%) and Burkina Faso (range 2-6%).
CONCLUSION
In Togolese individuals, the concentration of serum IgG against XPS was higher among the two older age groups as compared to the youngest age group. Antibody concentrations against MenX PS correlated significantly with SBA titers. This supports further development of a MenX PS based conjugate vaccine. Further studies are needed to verify the ability of MenX PS to induce SBA in humans.
背景
荚膜群 X 脑膜炎奈瑟菌（MenX）已成为撒哈拉以南非洲局部疾病暴发的原因，但人们对接触 MenX 抗原后产生的人体免疫反应知之甚少。因此，我们评估了生活在 2007 年多哥西部一个受 MenX 暴发影响地区的个体对 MenX 的自然免疫力。2009 年，300 名健康个体（100 名年龄在 3-5 岁、100 名年龄在 13-19 岁、100 名年龄在 20-25 岁）被纳入研究，并用来自英国和布基纳法索年龄匹配对照者的血清进行了比较。
方法
用兔补体测量 MenX 血清杀菌抗体（SBA），用 ELISA 定量测定 MenX 多糖（XPS）和外膜囊泡（XOMVs）抗体。
结果
3-5 岁个体中 SBA 滴度≥8 的 Togolese 个体比例为 29%（95%置信区间[CI]为 18-41），13-19 岁个体为 34%（95%CI 为 9-60），20-25 岁个体为 32%（95%CI 为 24-40）。这明显高于英国对照组（范围为 13-16%）和布基纳法索对照组（范围为 2-6%）。
结论
在 Togolese 个体中，与最年轻年龄组相比，XPS 的血清 IgG 浓度在两个年龄较大的年龄组中更高。MenX PS 抗体浓度与 SBA 滴度显著相关。这支持进一步开发基于 MenX PS 的结合疫苗。需要进一步的研究来验证 MenX PS 在诱导人类 SBA 方面的能力。
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