Oelschlägel Martin, Meyer Tobias, Schackert Gabriele, Kirsch Matthias, Sobottka Stephan B, Morgenstern Ute
Faculty of Electrical and Computer Engineering, Technische Universität Dresden, Institut für Biomedizinische Technik, D - 01307 Dresden, Germany, Phone: +49 351 463 32118, Fax: +49 351 463 36026.
Institute of Biomedical Engineering, Faculty of Electrical and Computer Engineering, Technische Universität Dresden, 01307 Dresden, Germany.
Biomed Tech (Berl). 2018 Oct 25;63(5):587-594. doi: 10.1515/bmt-2017-0156.
Brain tumor resection is even today one of the most challenging disciplines in neurosurgery. The current state of the art for the identification of tumor tissue during the surgical procedure comprises a wide variety of different tools, each with its own limitations and drawbacks. In this paper, we present a novel approach, the use of optical imaging in connection with direct electrical cortical stimulation (DCS), for identification of impaired tumor tissue and functional intact normal brain tissue under intraoperative conditions. Measurements with an optical imaging setup were performed as a proof of concept on three patients who underwent tumor resection of superficial gliomas. Direct electrical stimulations were applied on tumor tissue and surrounding brain tissue in each patient and characteristic features from the observed changes in the optical properties were compared between the different groups. The results reveal that in all patients a differentiation between non-functional tumor tissue and functional intact brain tissue was possible, and the technique might be a useful clinical tool in the future.
即使在今天，脑肿瘤切除术仍是神经外科最具挑战性的学科之一。手术过程中识别肿瘤组织的当前技术水平包括各种各样不同的工具，每种工具都有其自身的局限性和缺点。在本文中，我们提出了一种新颖的方法，即结合直接皮层电刺激（DCS）使用光学成像，用于在术中条件下识别受损的肿瘤组织和功能完整的正常脑组织。使用光学成像装置进行测量作为概念验证，对三名接受浅表胶质瘤肿瘤切除术的患者进行了研究。对每位患者的肿瘤组织和周围脑组织施加直接电刺激，并比较不同组之间观察到的光学特性变化的特征。结果表明，在所有患者中，区分无功能的肿瘤组织和功能完整的脑组织是可能的，并且该技术未来可能成为一种有用的临床工具。
