Kikkawa Kazuro, Iba Akinori, Kohjimoto Yasuo, Noda Yasutaka, Sonomura Tetsuo, Hara Isao
Department of Urology, Wakayama Medical University, Wakayama, Japan.
Department of Radiology, Wakayama Medical University, Wakayama, Japan.
Int J Urol. 2018 Apr;25(4):366-371. doi: 10.1111/iju.13530. Epub 2018 Feb 4.
To evaluate age-related quality of life changes in patients with localized prostate cancer treated by high-dose rate brachytherapy combined with external beam radiation therapy.
A total of 172 patients with clinically localized prostate cancer were categorized to age groups <75 years and ≥75 years. Changes in their quality of life were evaluated using the Japanese version of Medical Outcome Study 8-Items Short Form Health Survey, Expanded Prostate Cancer Index Composite and International Index of Erectile Function-5 at baseline, and followed up to 24 months after treatment.
There were no significant differences in Medical Outcome Study 8-Items Short Form Health Survey scores, and urinary and bowel scores of the Expanded Prostate Cancer Index Composite for older men after treatment. International Index of Erectile Function-5 summary scores were significantly decreased in both groups. Although sexual function and sexual bother scores were decreased in patients aged <75 years, these scores were maintained in patients aged ≥75 years.
Quality of life of prostate cancer patients undergoing high-dose rate brachytherapy combined with external beam radiation therapy does not seem to be significantly affected by age.
评估接受高剂量率近距离放射治疗联合外照射放疗的局限性前列腺癌患者与年龄相关的生活质量变化。
总共172例临床局限性前列腺癌患者被分为年龄小于75岁和大于等于75岁两个年龄组。使用日本版医学结局研究8项简表健康调查、扩展前列腺癌指数综合量表和国际勃起功能指数-5在基线时评估他们的生活质量变化，并在治疗后随访24个月。
治疗后老年男性的医学结局研究8项简表健康调查得分以及扩展前列腺癌指数综合量表的泌尿和肠道得分没有显著差异。两组的国际勃起功能指数-5总结得分均显著降低。虽然年龄小于75岁的患者性功能和性困扰得分降低，但年龄大于等于75岁的患者这些得分保持不变。
接受高剂量率近距离放射治疗联合外照射放疗的前列腺癌患者的生活质量似乎不受年龄的显著影响。
