Giam Y C, Tham S N, Tan T, Lim A
Ann Acad Med Singap. 1986 Jan;15(1):118-21.
Drug eruptions from indeginous medicine is often difficult to diagnosis and confirm. It is known that a number of these now supplied by bomohs and Chinese sinsehs contain known drugs and are dispensed as tablets and capsules. We report 3 cases of adverse drug eruption to "Jamu", a Malay herb. A particular brand, "Jamu Indonesia, Toko Air Pancur", from Johor Bahru, Malaysia, is especially recommended for "sakit pinggang" or backache. The cases occurred between January and February 1985, and all had taken brown kidney shaped tablets. The adverse reactions were moderately severe. Two had erythroderma with hepatitis, and one, Steven Johnson Syndrome. Analysis of this jamu for analgesics led to the discovery of adulteration with phenylbutazone and diazepam. Records from local cases from 1974-1984 showed that 8 other patients, all Chinese had adverse cutaneous eruptions from phenylbutazone, oxybutazone and propyphenazone. The skin manifestations were erythroderma (2 cases), vasculitis (2 cases) and toxic epidermal necrolysis (4 cases). Those with toxic epidermal necrolysis had 100% mortality.
来自传统药物的药疹往往难以诊断和确诊。据了解，现在巫医和中医所提供的许多此类药物都含有已知药物，并且是以片剂和胶囊形式配药的。我们报告了3例对马来草药“Jamu”的药物不良反应疹病例。特别推荐一种来自马来西亚柔佛州新山的特定品牌“Jamu Indonesia, Toko Air Pancur”用于治疗“sakit pinggang”或背痛。这些病例发生在1985年1月至2月之间，所有患者都服用了棕色肾形片剂。不良反应为中度严重。2例出现红皮病伴肝炎，1例出现史蒂文斯 - 约翰逊综合征。对这种Jamu进行的镇痛药分析发现其中掺有保泰松和地西泮。1974年至1984年当地病例记录显示，另外8名患者（均为华人）因保泰松、羟布宗和丙氧苯宗出现了皮肤不良反应疹。皮肤表现为红皮病（2例）、血管炎（2例）和中毒性表皮坏死松解症（4例）。患有中毒性表皮坏死松解症的患者死亡率为100%。
