非感染性主动脉炎：某地区医院使用托珠单抗的经验
Noninfectious aortitis: Experience with tocilizumab in a regional hospital.
作者信息
Aldasoro Cáceres Vicente, Ibáñez Bosch Rosario, Rivas Zavaleta Nathalí, Álvarez Rodríguez Belén, Intxausti Irazábal Juan José, Jiménez de Aberasturi Juan Ramón de Dios, Ruibal Escribano Ana, Maíz Alonso Olga, Calvo Alén Jaime
机构信息
Complejo Hospitalario de Navarra, Pamplona, España.
Complejo Hospitalario de Navarra, Pamplona, España.
出版信息
Reumatol Clin (Engl Ed). 2019 Nov-Dec;15(6):e96-e98. doi: 10.1016/j.reuma.2017.12.014. Epub 2018 Feb 15.
OBJECTIVES
Describe patients with noninfectious aortitis and their response to treatment in a regional hospital.
METHODS
Review of patients with noninfectious aortitis, diagnostic technique used and immunosuppressive therapy received.
RESULTS
We report 8 patients (7 women and one man) diagnosed with aortitis by positron emission tomography (PET). The mean age was 69years (interquartile range [IQR] 62-72.2). Three months of treatment with tocilizumab improved symptoms, erythrocyte sedimentation rate and C-reactive protein level (P<.001 and P<.012, respectively) in the 6 patients in whom it was used.
CONCLUSIONS
Tocilizumab was an effective and safe treatment in those patients diagnosed with aortitis refractory to steroids and conventional immunosuppressive therapy.
目的
描述在一家地区医院中患有非感染性主动脉炎的患者及其对治疗的反应。
方法
回顾患有非感染性主动脉炎的患者、所使用的诊断技术以及接受的免疫抑制治疗。
结果
我们报告了8例经正电子发射断层扫描（PET）诊断为主动脉炎的患者（7名女性和1名男性）。平均年龄为69岁（四分位间距[IQR]为62 - 72.2）。在使用托珠单抗治疗的6例患者中，治疗3个月后症状、红细胞沉降率和C反应蛋白水平均有所改善（分别为P<0.001和P<0.012）。
结论
对于诊断为对类固醇和传统免疫抑制治疗难治的主动脉炎患者，托珠单抗是一种有效且安全的治疗方法。
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