Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J
Annu Rev Immunol. 1986;4:593-619. doi: 10.1146/annurev.iy.04.040186.003113.
The role of the T3/antigen receptor complex is summarized by the diagram presented in Figure 4. Signals transmitted through T3/Ti activate a phosphodiesterase. This enzyme acts on its substrate PIP2 to generate two important mediators, IP3 and diacylglycerol. IP3 mobilizes calcium from bound intracellular stones. This increase in [Ca2+]i is one intracellular signal which, in conjunction with others, induces expression of lymphokine genes by influencing pretranslational, presumably transcriptional, events. Several problems remain. Which of the five molecules in the T3/Ti complex serves as the effector molecule in the transmembrane signaling process is not known. Which molecules serve to link T3/Ti to the phosphodiesterase enzyme is under investigation. The role diacylglycerol protein kinase C and other mediators play in signalling activation is not established. Finally, for those events occurring after the early events pictured in Figure 4 that result in gene activation, the sequence is a black box. Approaches to address each of these questions are available, and answers should be forthcoming.
T3/抗原受体复合物的作用如图4所示的图表所概括。通过T3/Ti传递的信号激活一种磷酸二酯酶。这种酶作用于其底物磷脂酰肌醇-4,5-二磷酸（PIP2）以产生两种重要的介质，即肌醇-1,4,5-三磷酸（IP3）和二酰基甘油。IP3从结合的细胞内储存库中动员钙。细胞内钙离子浓度（[Ca2+]i）的这种增加是一种细胞内信号，它与其他信号一起，通过影响翻译前（可能是转录）事件来诱导淋巴因子基因的表达。仍存在几个问题。T3/Ti复合物中的五个分子中哪一个在跨膜信号传导过程中作为效应分子尚不清楚。哪些分子将T3/Ti与磷酸二酯酶连接正在研究中。二酰基甘油、蛋白激酶C和其他介质在信号激活中所起的作用尚未确定。最后，对于图4中所示的导致基因激活的早期事件之后发生的那些事件，其顺序是一个未知领域。解决这些问题的方法是有的，答案应该会很快得出。
