Bennett Tristram C, Matz Brad M, Henderson Ralph A, Straw Rodney C, Liptak Julius M, Selmic Laura E, Collivignarelli Francesco, Buracco Paolo
Brisbane Veterinary Specialist Centre, Brisbane, Queensland, Australia.
Auburn University College of Veterinary Medicine, Auburn, Alabama.
Vet Surg. 2018 Apr;47(3):367-377. doi: 10.1111/vsu.12768. Epub 2018 Feb 5.
To describe the complications and outcome after total prostatectomy in dogs with histologically confirmed prostatic carcinoma.
Multi-institutional retrospective case series.
25 client-owned dogs.
Medical records of dogs undergoing total prostatectomy were reviewed from 2004 to 2016. Data retrieved included signalment, presenting signs, preoperative clinical findings, laboratory data, diagnostic imaging, surgical technique, histologic diagnosis, postoperative complications, occurrence of postoperative metastasis, and survival.
Twenty-five dogs underwent total prostatectomy for prostatic carcinoma. Urinary anastomotic techniques included urethrourethral anastomosis in 14 dogs, cystourethral anastomosis in 9 dogs, ureterocolonic anastomosis in 1 dog, and anastomosis between the bladder neck and penile urethra in 1 dog. All dogs survived to discharge. Fifteen dogs were diagnosed with transitional cell carcinoma, 8 dogs with prostatic adenocarcinoma, 1 with prostatic cystadenocarcinoma, and 1 with an undifferentiated carcinoma. Permanent postoperative urinary incontinence was present in 8 of 23 dogs. The median survival time was shorter in dogs with extracapsular tumor extension compared with those with intracapsular tumors. The overall median survival time was 231 days (range, 24-1255), with 1- and 2-year survival rates equal to 32% and 12%, respectively.
Total prostatectomy, combined with adjunct therapies, prolongs survival and lowers complication rates compared to previous reports of dogs with prostatic carcinoma. It should be noted, however, that case selection likely played a significant role in postoperative outcome.
描述经组织学确诊为前列腺癌的犬只行前列腺全切术后的并发症及预后情况。
多机构回顾性病例系列研究。
25只客户拥有的犬只。
回顾2004年至2016年接受前列腺全切术犬只的病历。收集的数据包括特征、就诊症状、术前临床检查结果、实验室数据、诊断性影像学检查、手术技术、组织学诊断、术后并发症、术后转移情况及生存情况。
25只犬只因前列腺癌接受了前列腺全切术。尿路吻合技术包括14只犬采用尿道尿道吻合术，9只犬采用膀胱尿道吻合术，1只犬采用输尿管结肠吻合术，1只犬采用膀胱颈与阴茎尿道吻合术。所有犬只均存活至出院。15只犬被诊断为移行细胞癌，8只犬为前列腺腺癌，1只犬为前列腺囊腺癌，1只犬为未分化癌。23只犬中有8只出现永久性术后尿失禁。与包膜内肿瘤的犬只相比，包膜外肿瘤扩展的犬只中位生存时间较短。总体中位生存时间为231天（范围24 - 1255天），1年和2年生存率分别为32%和12%。
与先前报道的前列腺癌犬只相比，前列腺全切术联合辅助治疗可延长生存期并降低并发症发生率。然而，应注意病例选择可能对术后结果起到了重要作用。
