Neumann Jan, Schmaderer Christoph, Finsterer Sebastian, Zimmermann Alexander, Steubl Dominik, Helfen Anne, Berninger Markus, Lohöfer Fabian, Rummeny Ernst J, Meier Reinhard, Wildgruber Moritz
Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Department of Nephrology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Clin Hemorheol Microcirc. 2018;70(1):69-81. doi: 10.3233/CH-170321.
Quantitative Imaging of microcirculatory disorders is challenging.
To investigate the feasibility of 2D Fluorescence Optical Imaging (FOI) for characterization and quantification of microcirculatory disorders in peripheral arterial occlusive disease (PAOD) of the upper extremity.
9 patients with various clinical presentations of PAOD of the upper extremity were included. Quantitative analysis of both hands was performed by assessing the fluorescence intensity of Indocyanine Green (ICG) dynamically over a time period of 360 seconds. Analysis of the signal intensity within multiple regions of both hands was calculated and time-dependent perfusion curves for each region of interest were plotted over time.
Compared to the healthy, vascular non-impaired segments, pathological segments with an impaired tissue perfusion were identified through a decreased rate of early tissue enhancement (p = 0.02) and increased signal intensity of the optical perfusion agent per second (p < 0.001). The affected segments showed a decreased maximum signal intensity and a prolonged interval to reach the maximum signal intensity (time to peak).
2D FOI allows quantitative assessment of the peripheral microcirculation in various vascular pathophysiologies and is able to detect the impaired tissue perfusion in patients with vascular disorders of the upper extremity.
微循环障碍的定量成像具有挑战性。
探讨二维荧光光学成像（FOI）在上肢外周动脉闭塞性疾病（PAOD）中表征和量化微循环障碍的可行性。
纳入9例具有上肢PAOD各种临床表现的患者。通过在360秒的时间段内动态评估吲哚菁绿（ICG）的荧光强度对双手进行定量分析。计算双手多个区域内的信号强度，并绘制每个感兴趣区域随时间的时间依赖性灌注曲线。
与健康、血管未受损节段相比，通过早期组织增强率降低（p = 0.02）和每秒光学灌注剂信号强度增加（p < 0.001）识别出组织灌注受损的病理节段。受影响节段显示最大信号强度降低，达到最大信号强度的间隔时间延长（达峰时间）。
二维FOI允许对各种血管病理生理学中的外周微循环进行定量评估，并能够检测上肢血管疾病患者的组织灌注受损情况。
