Seca Susana, Franconi Giovanna
Faculty of Medicine, University of Coimbra, 3045-137 Coimbra, Portugal.
Institute of Biomedical Sciences Abel Salazar, University of Porto, 4050-313 Porto, Portugal.
Medicines (Basel). 2018 Feb 3;5(1):17. doi: 10.3390/medicines5010017.
A considerable number of Rheumatoid Arthritis (RA) patients only experience side effects from treatment, with little to no actual pain relief. The combination of disease diagnosis in biomedicine and multi-disciplinary integrative approaches such as Chinese Medicine (CM), can help to identify different functional diagnosis of RA in the context of biomarker discovery. We aimed to analyse CM patterns in RA and their biomarker profiles. Four electronic databases (web of science, CINAHL, Scopus and PubMed) were searched. The reference list of all identified reports and articles were searched for additional studies. All study designs were included and no date limits were set. Studies were considered if they were published in English and explored the possible biomarkers profiles in RA patients, classified according to the American College of Rheumatology and categorized in CM as either cold, heat/hot or deficiency patterns. Methodological quality of included studies was assessed using checklists adapted from the ©Critical Appraisal Skills Programme by two independent reviewers. A narrative synthesis was conducted, using thematic analysis. A total of 10 articles were included. The studies examined 77 healthy volunteers and 1150 RA patients categorized as cold, heat/hot or deficiency pattern and related biomarkers were identified individually or concomitantly. : CM pattern differentiation based on clinical signs and symptoms showed a diverse range of biomolecules, proteins and genes from RA patients correlated well with cold, heat/hot or deficiency phenotype-based CM patterns and could be used as diagnostic biomarkers for early detection, disease monitoring and therapeutic targets.
相当数量的类风湿性关节炎（RA）患者仅经历治疗的副作用，而实际疼痛缓解甚微或没有缓解。生物医学中的疾病诊断与诸如中医（CM）等多学科综合方法相结合，有助于在生物标志物发现的背景下识别RA的不同功能诊断。我们旨在分析RA中的中医模式及其生物标志物谱。检索了四个电子数据库（科学网、护理学与健康领域数据库、Scopus和PubMed）。对所有已识别报告和文章的参考文献列表进行检索以寻找其他研究。纳入所有研究设计，不设日期限制。如果研究以英文发表并探讨了RA患者中可能的生物标志物谱，则予以考虑，这些研究根据美国风湿病学会进行分类，并在中医中归类为寒证、热证或虚证。由两名独立评审员使用改编自©批判性评估技能计划的清单评估纳入研究的方法学质量。采用主题分析进行叙述性综合。共纳入10篇文章。这些研究检查了77名健康志愿者和1150名被归类为寒证、热证或虚证的RA患者，并分别或同时鉴定了相关生物标志物。基于临床体征和症状的中医证型分化显示，RA患者的多种生物分子、蛋白质和基因与基于寒证、热证或虚证表型的中医模式密切相关，可作为早期检测、疾病监测和治疗靶点的诊断生物标志物。
