Clark E A, Ledbetter J A, Holly R C, Dinndorf P A, Shu G
Hum Immunol. 1986 May;16(1):100-13. doi: 10.1016/0198-8859(86)90039-x.
Two monoclonal antibodies (MoAbs), designated BB-1 and LB-2, react with distinct polypeptides expressed on activated human B cells. The BB-1 MoAb reacted with a 37,000-dalton polypeptide (Bp37) restricted to pre-B and B-cell blasts and B-cell malignancies. The LB-2 MoAb reacted with a 76,000-dalton polypeptide (p76) found on resting B cells but at higher levels on activated B cells and T cells. Buoyant tonsillar lymphoid cells with a germinal center phenotype express higher levels of Bp37 and p76 than do dense B cells of the mantle zone. Furthermore, the expression of Bp37 and p76 on tonsillar B-cell subsets was distinct from other B-cell antigens such as Bp39, Bp95, Bp135, the C3d receptor and surface IgM. Based on biochemical, cross-blocking, and tissue distribution analyses, these antigens appear to be distinct from previously described B cell and B-cell-blast markers.
两种单克隆抗体（MoAbs），分别命名为BB - 1和LB - 2，与活化的人B细胞上表达的不同多肽发生反应。BB - 1单克隆抗体与一种37000道尔顿的多肽（Bp37）发生反应，该多肽仅限于前B细胞、B细胞母细胞和B细胞恶性肿瘤。LB - 2单克隆抗体与一种76000道尔顿的多肽（p76）发生反应，该多肽存在于静止B细胞上，但在活化B细胞和T细胞上水平更高。具有生发中心表型的浮起扁桃体淋巴样细胞比套区致密B细胞表达更高水平的Bp37和p76。此外，Bp37和p76在扁桃体B细胞亚群上的表达与其他B细胞抗原如Bp39、Bp95、Bp135、C3d受体和表面IgM不同。基于生化、交叉阻断和组织分布分析，这些抗原似乎与先前描述的B细胞和B细胞母细胞标志物不同。
