Qiu Tingting, Wang Hong, Song Jinzhen, Guo Gang, Shi Yujun, Luo Yan, Liu Jibin
Department of Ultrasound, West China Hospital of Sichuan University, Chengdu, China.
Research Institute of Pathology, West China Hospital of Sichuan University, Chengdu, China.
Ultrasound Med Biol. 2018 Apr;44(4):779-785. doi: 10.1016/j.ultrasmedbio.2017.12.015. Epub 2018 Feb 3.
The purpose of this study was to investigate whether ultrasound elastography reflects liver function reserve relative to liver fibrosis histology. Sixty-five New Zealand rabbits were divided into an experimental group (n = 45) and a control group (n = 20). In the experimental group, liver fibrosis (F1-F4) was induced by subcutaneous injection of carbon tetrachloride. Point shear wave elastography and the indocyanine green (ICG) elimination test were performed for the two groups at 4-wk intervals for 56 wk. The liver stiffness value (LSV) and the ICG retention rate at 15 min (ICGR15) were obtained, and the correlation between them was investigated. The median LSVs of stages F0-F4 were 3.92 kPa (1.91-8.53 kPa), 5.02 kPa (2.39-8.91 kPa), 7.87 kPa (5.21-12.26 kPa), 12.83 kPa (5.92-16.79 kPa) and 16.64 kPa (9.76-29.50 kPa), respectively. The median ICGR15 values of stages F0-F4 were 8.7% (4.8%-15.6%), 10.8% (5.6%-20.3%), 19.2% (12.3%-26.7%), 31.0% (20.9%-41.0%) and 45.6% (22.1%-60.9%). There were significant differences in LSVs and ICGR15 values among the different stages of liver fibrosis (p <0.01). A positive correlation was observed between LSV and ICGR15 (r = 0.7497, p < 0.0001). A strong correlation was observed between liver stiffness and liver function reserve, indicating ultrasound elastography may reflect liver function reserve in different degrees of liver fibrosis.
本研究的目的是探讨超声弹性成像是否能反映相对于肝纤维化组织学的肝功能储备情况。将65只新西兰兔分为实验组（n = 45）和对照组（n = 20）。在实验组中，通过皮下注射四氯化碳诱导肝纤维化（F1 - F4）。两组分别每隔4周进行一次点剪切波弹性成像和吲哚菁绿（ICG）清除试验，共进行56周。获取肝脏硬度值（LSV）和15分钟时的ICG滞留率（ICGR15），并研究它们之间的相关性。F0 - F4期的LSV中位数分别为3.92 kPa（1.91 - 8.53 kPa）、5.02 kPa（2.39 - 8.91 kPa）、7.87 kPa（5.21 - 12.26 kPa）、12.83 kPa（5.92 - 16.79 kPa）和16.64 kPa（9.76 - 29.50 kPa）。F0 - F4期的ICGR15中位数分别为8.7%（4.8% - 15.6%）、10.8%（5.6% - 20.3%）、19.2%（12.3% - 26.7%）、31.0%（20.9% - 41.0%）和45.6%（22.1% - 60.9%）。肝纤维化不同阶段的LSV和ICGR15值存在显著差异（p < 0.01）。观察到LSV与ICGR15之间呈正相关（r = 0.7497，p < 0.0001）。观察到肝脏硬度与肝功能储备之间存在强相关性，表明超声弹性成像可能在不同程度的肝纤维化中反映肝功能储备。
