Department of Pathology and Laboratory Medicine, The University of British Columbia, Vancouver, BC, Canada.
Division of Anatomical Pathology, Vancouver General Hospital, Vancouver, BC, Canada.
Mod Pathol. 2018 Jun;31(6):862-872. doi: 10.1038/s41379-018-0028-4. Epub 2018 Feb 6.
Tumor budding, defined as single cells or clusters of less than five cells, is thought to be a histomorphologic marker of an aggressive tumor behavior mimicking the embryologic epithelial-mesenchymal transition, and has been well established in the past two decades as a poor prognostic factor in colorectal carcinoma. Slow uptake in routine reporting of this important pathologic prognostic feature was in part due to differing methods of assessment of budding reported in the literature, but has recently been clarified at a consensus conference on tumor budding in colorectal carcinoma. Tumor budding is also increasingly being reported as a useful pathologic prognostic feature in other gastrointestinal carcinomas, including esophageal squamous cell carcinoma and adenocarcinoma, gastric intestinal-type adenocarcinoma, pancreatic ductal adenocarcinoma, and ampullary adenocarcinoma. In this review, we will summarize the studies on tumor budding in gastrointestinal carcinomas, with a focus on the methods of assessment used and the potential clinical applications of the findings.
肿瘤芽殖，定义为少于五个细胞的单个细胞或细胞簇，被认为是一种模仿胚胎上皮-间充质转化的侵袭性肿瘤行为的组织形态学标志物，在过去二十年中已被确立为结直肠癌的预后不良因素。这种重要的病理预后特征在常规报告中的缓慢采用部分归因于文献中报道的芽殖评估方法的不同，但最近在结直肠癌肿瘤芽殖共识会议上得到了澄清。肿瘤芽殖也越来越多地被报道为其他胃肠道癌（包括食管鳞状细胞癌和腺癌、胃肠型腺癌、胰腺导管腺癌和壶腹腺癌）中有用的病理预后特征。在这篇综述中，我们将总结胃肠道癌中肿瘤芽殖的研究，重点介绍使用的评估方法以及研究结果的潜在临床应用。
