Nakagawa Yuichi, Nakanishi Toshiki, Satake Eiichiro, Matsushita Rie, Saegusa Hirokazu, Kubota Akira, Natsume Hiromune, Shibata Yukinobu, Fujisawa Yasuko
Department of Internal Medicine and Pediatrics, Shiraume Toyooka Hospital, Shizuoka, Japan.
Department of Pediatrics, Hamamatsu University School of Medicine, Shizuoka, Japan.
Clin Pediatr Endocrinol. 2018;27(1):19-29. doi: 10.1297/cpe.27.19. Epub 2018 Jan 30.
The purpose of this study was to clarify the degree of early postnatal growth by birthweight and detect early predictive factors for pediatric obesity. Body mass index (BMI) and degree of obesity were examined in children in the fourth year of elementary school and second year of junior high school. Their BMI at birth and three years of age were also examined. Based on birthweight, participants were divided into three groups: low (< 2500 g), middle (2500-3500 g), and high (> 3500 g). Furthermore, according to the degree of obesity, they were divided into two groups: obese (20% ≤) and non-obese (20% >). The change of BMI from birth to three years of age (ΔBMI) showed a strong inverse relationship with birthweight and was significantly different among the three birthweight groups (low > middle > high). The ΔBMI and BMI at three years of age were higher in obese than in non-obese children and showed significant positive correlations with the degree of obesity. Early postnatal growth might be determined by birthweight and was higher in obese than in non-obese children. The ΔBMI from birth to three years of age and BMI at age of three years could be predictive factors for pediatric obesity.
本研究的目的是通过出生体重阐明出生后早期生长的程度，并检测儿童肥胖的早期预测因素。对小学四年级和初中二年级的儿童进行了体重指数（BMI）和肥胖程度检查。还检查了他们出生时和三岁时的BMI。根据出生体重，参与者被分为三组：低体重（<2500克）、中等体重（2500 - 3500克）和高体重（>3500克）。此外，根据肥胖程度，他们被分为两组：肥胖（20%≤）和非肥胖（20%>）。从出生到三岁的BMI变化（ΔBMI）与出生体重呈强烈负相关，且在三个出生体重组之间存在显著差异（低体重>中等体重>高体重）。肥胖儿童的ΔBMI和三岁时的BMI高于非肥胖儿童，且与肥胖程度呈显著正相关。出生后早期生长可能由出生体重决定，且肥胖儿童高于非肥胖儿童。从出生到三岁的ΔBMI和三岁时的BMI可能是儿童肥胖的预测因素。
