Sugimoto Y, Yamada J, Horisaka K
J Pharmacobiodyn. 1986 Jan;9(1):68-73. doi: 10.1248/bpb1978.9.68.
The effects of tryptamine (TRM) on behavior were investigated in mice. TRM at a dose of 50 mg/kg i.p. induced an inhibition of locomotor activity and, at doses ranging from 150 to 300 mg/kg, induced peculiar behaviors such as head twitch, head weaving, forepaw treading, hindlimb abduction and Straub tail. These behavioral effects were continuous, although TRM rapidly disappeared from the brain. Methysergide, a 5-hydroxytryptamine (5-HT) receptor antagonist, completely abolished TRM-induced excitatory behaviors and p-chlorophenylalanine, a 5-HT depleter, significantly inhibited the behaviors. Our results show that TRM induced both the depression and excitation in the behavior of mice depending on the dosage and TRM-induced excitatory behaviors may be attributed to both its direct stimulation of 5-HT receptors and facilitation of 5-HT release.
研究了色胺（TRM）对小鼠行为的影响。腹腔注射50mg/kg剂量的TRM可抑制运动活性，而150至300mg/kg剂量的TRM会诱发诸如头部抽搐、头部摆动、前爪踩踏、后肢外展和斯特劳布尾等特殊行为。尽管TRM迅速从大脑中消失，但这些行为效应仍持续存在。5-羟色胺（5-HT）受体拮抗剂美西麦角可完全消除TRM诱导的兴奋行为，5-HT耗竭剂对氯苯丙氨酸可显著抑制这些行为。我们的结果表明，TRM根据剂量不同可诱导小鼠行为出现抑制和兴奋，且TRM诱导的兴奋行为可能归因于其对5-HT受体的直接刺激以及对5-HT释放的促进作用。
