Yang Hong-Ying, Zhang Wen-Meng, Yang Wen-Wen, Zhao Ting, Sun Li-Xin
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liaoning Institute of Pharmaceutical Industry, Shenyang 110015, China.
J Pharm Anal. 2011 May;1(2):135-138. doi: 10.1016/S2095-1779(11)70023-5. Epub 2012 Jan 30.
The pharmacokinetics of 16-dehydropregnenolone (16-DHP), a sterols compound isolated from Thunb., was investigated in rats following a Single intramuscular administration (40 mg/kg). The concentration of 16-DHP in rat plasma was determined by a high Performance liquid chromatography (HPLC) method with UV detection. Levonorgestrel was used as the internal Standard (IS). The pharmacokinetic parameters of 16-DHP were derived by non-compartmental method. After a Single intramuscular administration, the maximum plasma concentration () was (289 ± 25) ng/mL, time to reach () was (0.38 ± 0.14) h, the elimination half-life () was (2.5 ± 1.1) h, the area under the plasma concentration-time curve from time zero to the time of the last measurable concentration (AUC) was (544 ± 73)ng · h/mL. The results indicated that 16-DHP was absorbed quickly and eliminated rapidly in rats after the intramuscular injection.
对从[植物名称]中分离出的甾醇化合物16 - 脱氢孕烯醇酮（16 - DHP），在大鼠单次肌内注射（40毫克/千克）后进行了药代动力学研究。采用带紫外检测的高效液相色谱（HPLC）法测定大鼠血浆中16 - DHP的浓度。左炔诺孕酮用作内标（IS）。16 - DHP的药代动力学参数通过非房室方法得出。单次肌内注射后，血浆最大浓度（(C_{max})）为（289 ± 25）纳克/毫升，达峰时间（(t_{max})）为（0.38 ± 0.14）小时，消除半衰期（(t_{1/2})）为（2.5 ± 1.1）小时，从零时间到最后可测浓度的血浆浓度 - 时间曲线下面积（AUC）为（544 ± 73）纳克·小时/毫升。结果表明，16 - DHP在大鼠肌内注射后吸收迅速且消除快速。
