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用于同时测定某些含有非甾体抗炎药的药物二元混合物的选择性胶束电动色谱法。

Selective micellar electrokinetic chromatographic method for simultaneous determination of some pharmaceutical binary mixtures containing non-steroidal anti-inflammatory drugs.

作者信息

El-Kommos Michael E, Mohamed Niveen A, Abdel Hakiem Ahmed F

机构信息

Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.

出版信息

J Pharm Anal. 2013 Feb;3(1):53-60. doi: 10.1016/j.jpha.2012.07.005. Epub 2012 Jul 26.

DOI:10.1016/j.jpha.2012.07.005
PMID:29403796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5760936/
Abstract

A simple and selective micellar electrokinetic chromatographic (MEKC) method has been developed for the analysis of five pharmaceutical binary mixtures containing three non-steroidal anti-inflammatory drugs (NSAIDs). The investigated mixtures were Ibuprofen (IP)-Paracetamol (PC), Ibuprofen (IP)-Chlorzoxazone (CZ), Ibuprofen (IP)-Methocarbamol (MC), Ketoprofen (KP)-Chlorzoxazone (CZ) and Diclofenac sodium (DS)-Lidocaine hydrochloride (LC). The separation was run for all mixtures using borate buffer (20 mM, pH 9) containing 15% (v/v) methanol and 100 mM sodium dodecyl sulphate (SDS) at 15 kV and the components were detected at 214 nm. Different factors affecting the electrophoretic mobility of the seven investigated drugs were studied and optimized. The method was validated according to international conference of harmonization (ICH) guidelines and United States pharmacopoeia (USP). The method was applied to the analysis of five pharmaceutical binary mixtures in their dosage forms. The results were compared with other reported high performance liquid chromatographic methods and no significant differences were observed.

摘要

已开发出一种简单且具有选择性的胶束电动毛细管色谱法（MEKC），用于分析含有三种非甾体抗炎药（NSAIDs）的五种药物二元混合物。所研究的混合物为布洛芬（IP）-对乙酰氨基酚（PC）、布洛芬（IP）-氯唑沙宗（CZ）、布洛芬（IP）-美索巴莫（MC）、酮洛芬（KP）-氯唑沙宗（CZ）和双氯芬酸钠（DS）-盐酸利多卡因（LC）。使用含有15%（v/v）甲醇和100 mM十二烷基硫酸钠（SDS）的硼酸盐缓冲液（20 mM，pH 9），在15 kV电压下对所有混合物进行分离，并在214 nm处检测各成分。研究并优化了影响七种所研究药物电泳迁移率的不同因素。该方法根据国际协调会议（ICH）指南和美国药典（USP）进行了验证。该方法应用于分析五种药物二元混合物的剂型。将结果与其他报道的高效液相色谱法进行比较，未观察到显著差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/cd2fed477a81/fx00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/cfa8550c5214/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/d46c775ddd53/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/9d5ec1855360/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/cd2fed477a81/fx00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/cd2fed477a81/fx00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/cfa8550c5214/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/d46c775ddd53/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/9d5ec1855360/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/cd2fed477a81/fx00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/5760936/cd2fed477a81/fx00.jpg

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