Reid Imad O Abu, Osman Sayda M, Bakheet Somia M
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, International University of Africa, Khartoum, Sudan.
J Anal Methods Chem. 2025 Jul 30;2025:6822390. doi: 10.1155/jamc/6822390. eCollection 2025.
The fixed-dose combination (FDC) of ibuprofen (IBU) and paracetamol (PAR) has emerged as a preferred option in pain management, owing to its distinct practical advantages. Both drugs have well-documented efficacy and safety profiles, providing synergistic pain relief through complementary mechanisms of action. IBU not only offers central analgesic effects but also inhibits cyclooxygenase (COX) enzymes, particularly COX-1 and COX-2, thereby reducing prostaglandin synthesis at the site of pain to deliver both analgesic and anti-inflammatory benefits. Despite the growing use of this combination, a comprehensive review focusing on the analytical methods for its determination has not yet been published. This review aims to bridge that gap by presenting an extensive compilation of documented analytical methods for the quantification of IBU and PAR in both bulk and pharmaceutical formulations. It serves as a valuable resource for researchers and professionals seeking detailed insights into the diverse techniques employed for accurate and precise analysis of these FDCs. Through a systematic search of major scientific databases, including Science Direct, Springer Link, PubMed, Scopus, and Google Scholar, the review identifies the most commonly utilized methods, such as high-performance liquid chromatography (HPLC), gas chromatography (GC), high-performance thin-layer chromatography (HPTLC), ultraviolet (UV)/Visible spectrophotometry, Fourier-transform infrared spectroscopy (FTIR), and micellar electrokinetic chromatography (MEKC). Notably, HPLC and UV/Visible spectrophotometry were the most frequently reported, each accounting for 37.9% of studies. By consolidating these analytical approaches, this review highlights the state-of-the-art methodologies available for the determination of IBU/PAR FDCs and underscores its novel contribution as a definitive reference for future research and development in this field.
布洛芬（IBU）和对乙酰氨基酚（PAR）的固定剂量复方制剂（FDC）因其独特的实际优势，已成为疼痛管理中的首选方案。两种药物都有充分记录的疗效和安全性概况，通过互补的作用机制提供协同性疼痛缓解。IBU不仅具有中枢镇痛作用，还能抑制环氧化酶（COX），特别是COX-1和COX-2，从而减少疼痛部位的前列腺素合成，带来镇痛和抗炎益处。尽管这种复方制剂的使用日益广泛，但尚未发表一篇专注于其测定分析方法的全面综述。本综述旨在填补这一空白，通过广泛汇编已记录的用于定量原料药和药物制剂中IBU和PAR的分析方法。它为寻求深入了解用于准确精确分析这些FDC的各种技术的研究人员和专业人士提供了宝贵资源。通过系统检索包括Science Direct、Springer Link、PubMed、Scopus和Google Scholar在内的主要科学数据库，该综述确定了最常用的方法，如高效液相色谱法（HPLC）、气相色谱法（GC）、高效薄层色谱法（HPTLC）、紫外（UV）/可见分光光度法、傅里叶变换红外光谱法（FTIR）和胶束电动色谱法（MEKC）。值得注意的是，HPLC和UV/可见分光光度法报道最为频繁，各占研究的37.9%。通过整合这些分析方法，本综述突出了可用于测定IBU/PAR FDC的最新方法，并强调了其作为该领域未来研发的权威性参考的新贡献。
