• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

同时接受氨甲环酸治疗的心脏外科手术患者血浆的代谢谱分析：直接浸入式固相微萃取-液相色谱-质谱联用分析

Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME-LC-MS analysis.

作者信息

Bojko Barbara, Wąsowicz Marcin, Pawliszyn Janusz

机构信息

Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1.

Department of Anesthesia, Toronto General Hospital, Toronto, Ontario, Canada M5G 2C4.

出版信息

J Pharm Anal. 2014 Feb;4(1):6-13. doi: 10.1016/j.jpha.2013.03.002. Epub 2013 Apr 11.

DOI:10.1016/j.jpha.2013.03.002
PMID:29403864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5761052/
Abstract

A metabolic profile of plasma samples from patients undergoing heart surgery with the use of cardiopulmonary bypass (CPB) and concurrent administration of tranexamic acid was determined. Direct immersion solid phase microextraction (DI-SPME), a new sampling and sample preparation tool for metabolomics, was used in this study for the first time to investigate clinical samples. The results showed alteration of diverse compounds involved in different biochemical pathways. The most significant contribution in changes induced by surgery and applied pharmacotherapy was noticed in metabolic profile of lysophospholipids, triacylglycerols, mediators of platelet aggregation, and linoleic acid metabolites. Two cases of individual response to treatment were also reported.

摘要

对接受体外循环（CPB）心脏手术并同时给予氨甲环酸的患者的血浆样本进行了代谢谱分析。直接浸入式固相微萃取（DI-SPME）是一种用于代谢组学的新型采样和样品制备工具，本研究首次将其用于临床样本研究。结果显示，参与不同生化途径的多种化合物发生了改变。在溶血磷脂、三酰甘油、血小板聚集介质和亚油酸代谢物的代谢谱中，观察到手术和应用药物治疗引起的变化中最显著的影响。还报告了两例个体对治疗的反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/cd2fed477a81/fx00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/545c0429490d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/336a05990b77/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/72c30b31b244/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/bb9ec2b3e348/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/cd2fed477a81/fx00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/545c0429490d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/336a05990b77/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/72c30b31b244/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/bb9ec2b3e348/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8592/5761052/cd2fed477a81/fx00.jpg

相似文献

1
Metabolic profiling of plasma from cardiac surgical patients concurrently administered with tranexamic acid: DI-SPME-LC-MS analysis.同时接受氨甲环酸治疗的心脏外科手术患者血浆的代谢谱分析：直接浸入式固相微萃取-液相色谱-质谱联用分析
J Pharm Anal. 2014 Feb;4(1):6-13. doi: 10.1016/j.jpha.2013.03.002. Epub 2013 Apr 11.
2
Solid phase microextraction as a powerful alternative for screening of secondary metabolites in actinomycetes.固相微萃取作为一种强大的替代方法，用于筛选放线菌中的次生代谢产物。
J Mass Spectrom. 2019 Oct;54(10):823-833. doi: 10.1002/jms.4434. Epub 2019 Oct 18.
3
Use of a novel technique, solid phase microextraction, to measure tranexamic acid in patients undergoing cardiac surgery.使用固相微萃取新技术测量心脏手术患者中的氨甲环酸。
Can J Anaesth. 2012 Jan;59(1):14-20. doi: 10.1007/s12630-011-9614-3. Epub 2011 Nov 2.
4
Therapeutic monitoring of tranexamic acid concentration: high-throughput analysis with solid-phase microextraction.氨甲环酸浓度的治疗药物监测：固相微萃取的高通量分析。
Ther Drug Monit. 2012 Feb;34(1):31-7. doi: 10.1097/FTD.0b013e3182400540.
5
Development of SPME method for concomitant sample preparation of rocuronium bromide and tranexamic acid in plasma.血浆中罗库溴铵和氨甲环酸同时样品制备的固相微萃取方法的开发。
J Pharm Biomed Anal. 2014 Apr;92:183-92. doi: 10.1016/j.jpba.2014.01.026. Epub 2014 Jan 27.
6
Application of solid phase microextraction for quantitation of polyunsaturated fatty acids in biological fluids.
Anal Chem. 2014 Dec 16;86(24):12022-9. doi: 10.1021/ac502627w. Epub 2014 Dec 2.
7
Comparison of the Conventional and Electroenhanced Direct-Immersion Solid-Phase Microextraction for Sampling of Nicotine in Biological Fluids of the Human Body.常规与电增强直接浸入式固相微萃取法在人体生物体液中尼古丁采样的比较。
Molecules. 2018 May 14;23(5):1171. doi: 10.3390/molecules23051171.
8
Solid phase microextraction coupled to mass spectrometry via a microfluidic open interface for rapid therapeutic drug monitoring.固相微萃取-微流控开放式接口质谱联用快速测定治疗药物。
Analyst. 2019 Jun 21;144(12):3721-3728. doi: 10.1039/c9an00041k. Epub 2019 Apr 10.
9
Solid phase microextraction coupled with comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for high-resolution metabolite profiling in apples: implementation of structured separations for optimization of sample preparation procedure in complex samples.固相微萃取结合全二维气相色谱飞行时间质谱用于苹果中高分辨率代谢物分析：结构化分离在复杂样品样品制备优化中的实现。
J Chromatogr A. 2012 Aug 17;1251:208-218. doi: 10.1016/j.chroma.2012.06.052. Epub 2012 Jun 23.
10
Determination of tranexamic acid concentration by solid phase microextraction and liquid chromatography-tandem mass spectrometry: first step to in vivo analysis.固相微萃取和液相色谱-串联质谱法测定氨甲环酸浓度：体内分析的第一步。
J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Dec 15;879(32):3781-7. doi: 10.1016/j.jchromb.2011.08.003. Epub 2011 Aug 10.

引用本文的文献

1
Urinary metabolomics to develop predictors for pediatric acute kidney injury.应用尿液代谢组学开发儿科急性肾损伤预测因子。
Pediatr Nephrol. 2022 Sep;37(9):2079-2090. doi: 10.1007/s00467-021-05380-6. Epub 2022 Jan 10.
2
Exploring the Lipidome: Current Lipid Extraction Techniques for Mass Spectrometry Analysis.探索脂质组学：用于质谱分析的当前脂质提取技术
Metabolites. 2020 Jun 3;10(6):231. doi: 10.3390/metabo10060231.

本文引用的文献

1
In vivo solid-phase microextraction: capturing the elusive portion of metabolome.体内固相微萃取：捕获代谢组中难以捉摸的部分。
Angew Chem Int Ed Engl. 2011 May 27;50(23):5344-8. doi: 10.1002/anie.201006715. Epub 2011 Apr 20.
2
Systematic evaluation of solid-phase microextraction coatings for untargeted metabolomic profiling of biological fluids by liquid chromatography-mass spectrometry.系统评价固相微萃取涂层在液相色谱-质谱联用技术下对生物体液进行非靶向代谢组学分析的应用。
Anal Chem. 2011 Mar 15;83(6):1944-54. doi: 10.1021/ac102614v. Epub 2011 Feb 18.
3
Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid.
心脏直视手术后的癫痫发作：ε-氨基己酸与氨甲环酸的比较。
J Cardiothorac Vasc Anesth. 2011 Feb;25(1):20-5. doi: 10.1053/j.jvca.2010.10.007.
4
Tranexamic acid in cardiac surgery: is there a cause for concern?氨甲环酸在心脏手术中的应用：是否需要引起关注？
Crit Care. 2010;14(5):194. doi: 10.1186/cc9227. Epub 2010 Sep 6.
5
HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate.高密度脂蛋白 3 可刺激脂肪细胞释放纤溶酶原激活物抑制剂-1，但高密度脂蛋白 2 不可：这与鞘氨醇-1-磷酸有关。
J Lipid Res. 2010 Sep;51(9):2619-28. doi: 10.1194/jlr.M003988. Epub 2010 Jun 3.
6
High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.高剂量氨甲环酸与心脏外科患者的非缺血性临床癫痫发作有关。
Anesth Analg. 2010 Feb 1;110(2):350-3. doi: 10.1213/ANE.0b013e3181c92b23. Epub 2009 Dec 8.
7
UPLC-MS-based analysis of human plasma for metabonomics using solvent precipitation or solid phase extraction.基于超高效液相色谱-质谱联用技术，采用溶剂沉淀法或固相萃取法对人血浆进行代谢组学分析。
J Proteome Res. 2009 Apr;8(4):2114-21. doi: 10.1021/pr801045q.
8
Effects of haemofiltration and mannitol treatment on cardiopulmonary-bypass induced immunosuppression.
Scand J Immunol. 2009 Mar;69(3):234-41. doi: 10.1111/j.1365-3083.2008.02216.x.
9
Automated study of ligand-receptor binding using solid-phase microextraction.使用固相微萃取对配体-受体结合进行自动化研究。
J Pharm Biomed Anal. 2009 Nov 1;50(4):550-5. doi: 10.1016/j.jpba.2008.08.023. Epub 2008 Aug 29.
10
Changes in plasma LDL and HDL composition in patients undergoing cardiac surgery.心脏手术患者血浆低密度脂蛋白和高密度脂蛋白成分的变化。
Lipids. 2007 Dec;42(12):1143-53. doi: 10.1007/s11745-007-3114-9. Epub 2007 Oct 3.