Pedersen-Bjergaard Stig, Huang Chuixiu, Gjelstad Astrid
School of Pharmacy, University of Oslo, P.O. Box 1068 Blindern, 0316 Oslo, Norway.
Faculty of Health and Medical Sciences, School of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
J Pharm Anal. 2017 Jun;7(3):141-147. doi: 10.1016/j.jpha.2017.04.002. Epub 2017 Apr 12.
Electromembrane extraction (EME) is an analytical microextraction technique, where charged analytes (such as drug substances) are extracted from an aqueous sample (such as a biological fluid), through a supported liquid membrane (SLM) comprising a water immiscible organic solvent, and into an aqueous acceptor solution. The driving force for the extraction is an electrical potential (dc) applied across the SLM. In this paper, EME is reviewed. First, the principle for EME is explained with focus on extraction of cationic and anionic analytes, and typical performance data are presented. Second, papers published in 2016 are reviewed and discussed with focus on (a) new SLMs, (b) new support materials for the SLM, (c) new sample additives improving extraction, (d) new technical configurations, (e) improved theoretical understanding, and (f) pharmaceutical new applications. Finally, important future research objectives and directions are defined for further development of EME, with the aim of establishing EME in the toolbox of future analytical laboratories.
电膜萃取（EME）是一种分析微萃取技术，在该技术中，带电分析物（如药物物质）从水性样品（如生物流体）中通过由与水不混溶的有机溶剂组成的支撑液膜（SLM）萃取到水性接受液中。萃取的驱动力是施加在支撑液膜上的电势（直流）。本文对电膜萃取进行了综述。首先，解释了电膜萃取的原理，重点是阳离子和阴离子分析物的萃取，并给出了典型的性能数据。其次，对2016年发表的论文进行了综述和讨论，重点关注（a）新型支撑液膜，（b）支撑液膜的新型支撑材料，（c）改善萃取的新型样品添加剂，（d）新型技术配置，（e）理论认识的提高，以及（f）药物新应用。最后，为电膜萃取的进一步发展确定了重要的未来研究目标和方向，旨在将电膜萃取纳入未来分析实验室的工具库。
