在离体灌注大鼠心脏中血栓素作用的拮抗作用。

Antagonism of thromboxane actions in the isolated perfused rat heart.

作者信息

Stahl G L, Darius H, Lefer A M

出版信息

Life Sci. 1986 Jun 2;38(22):2037-41. doi: 10.1016/0024-3205(86)90152-9.

Abstract

The effects of SQ-29,548, a novel thromboxane A2 (TxA2) receptor antagonist, were studied in the isolated perfused rat heart. SQ-29,548 at concentrations of 2.5 to 50 ng/ml antagonized the increase in coronary perfusion pressure (CPP) in response to the thromboxane agonist, 9,11-methanoepoxy PGH2. Increases in CPP induced by arginine vasopressin and leukotriene D4 were not altered by SQ-29,548. We conclude that SQ-29,548 is a very potent and specific TxA2 receptor antagonist in the coronary vasculature of the rat heart.

摘要

研究了新型血栓素A2（TxA2）受体拮抗剂SQ - 29,548对离体灌注大鼠心脏的作用。浓度为2.5至50 ng/ml的SQ - 29,548可拮抗血栓素激动剂9,11 - 甲撑环氧PGH2引起的冠状动脉灌注压（CPP）升高。精氨酸加压素和白三烯D4诱导的CPP升高不受SQ - 29,548影响。我们得出结论，SQ - 29,548是大鼠心脏冠状动脉血管中一种非常强效且特异性的TxA2受体拮抗剂。