手性三唑亚基-钯-PEPPSI：合成、表征及其在不对称铃木-宫浦交叉偶联反应中的应用
Chiral triazolylidene-Pd-PEPPSI: synthesis, characterization, and application in asymmetric Suzuki-Miyaura cross-coupling.
作者信息
Haraguchi Ryosuke, Hoshino Shun, Yamazaki Tatsuro, Fukuzawa Shin-Ichi
机构信息
Department of Applied Chemistry, Institute of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.
出版信息
Chem Commun (Camb). 2018 Feb 22;54(17):2110-2113. doi: 10.1039/c7cc09960f.
A chiral triazolylidene-Pd-PEPPSI (PEPPSI = pyridine, enhanced, precatalyst, preparation, stabilization, initiation) complex with ferrocene-based planar chirality has been synthesized and characterized. Investigation of the electronic and steric nature of this complex revealed its powerful electron-donating ability (TEP 2044 cm) and high steric bulk (%V = 42.2). These unique properties allow the complex to exhibit very high catalytic activity (TON = 420) for asymmetric Suzuki-Miyaura cross-coupling, providing the coupling product with good enantioselectivity (75% ee).
一种具有基于二茂铁的平面手性的手性三唑亚基-Pd-PEPPSI（PEPPSI=吡啶、增强、预催化剂、制备、稳定化、引发）配合物已被合成并表征。对该配合物的电子和空间性质的研究揭示了其强大的给电子能力（TEP 2044 cm）和高空间位阻（%V=42.2）。这些独特的性质使该配合物在不对称铃木-宫浦交叉偶联反应中表现出非常高的催化活性（TON=420），为偶联产物提供了良好的对映选择性（75%ee）。
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