Department of Biomedicine and Prevention, University Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.
IRCCS Neuromed, Pozzilli, Italy.
Mol Imaging Biol. 2018 Aug;20(4):659-666. doi: 10.1007/s11307-018-1167-1.
The present study was aimed to investigate the relationships between dysfunction of cortical glucose metabolism as detectable by means of 2-deoxy-2-[F]fluoro -D-glucose ([F]FDG) positron emission tomography/x-ray computed tomography (PET/CT) and amyloid burden as detectable by means of 4-{(E)-2-[4-(2-{2-[2-[F]fluoroethoxy]ethoxy}ethoxy)phenyl]vinyl}-N-methylaniline (florbetaben; [F]FBB) in a group of patients affected by Alzheimer's disease (AD).
We examined 38 patients newly diagnosed with AD according to the NINCDS-ADRDA criteria. All the subjects underwent a PET/CT scan using both [F]FDG and [F]FBB with an average interval of 1 month. We used statistical parametric mapping (SPM8) implemented in Matlab R2012b and WFU pickatlas for the definition of a region of interest (ROI) mask including the whole cortex. These data were then normalized on the counts of the cerebellum and then used for a regression analysis on [F]FDG scans in SPM. Furthermore, 58 control subjects were used as control group for [F]FDG PET/CT scans.
SPM analysis in AD patients showed a significant negative correlation between [F] FBB and [F] FDG uptake in temporal and parietal lobes bilaterally. Of note, these areas in AD patients displayed a marked glucose hypometabolism compared to control group.
Combined imaging with [F]FBB and [FFDG shows that amyloid burden in the brain is related to cortical dysfunction of temporal and parietal lobes in AD.
本研究旨在探讨通过 2-脱氧-2-[F]氟-D-葡萄糖([F]FDG)正电子发射断层扫描/X 射线计算机断层扫描(PET/CT)检测到的皮质葡萄糖代谢功能障碍与通过 4-{(E)-2-[4-(2-{2-[2-[F]氟乙氧基]乙氧基}乙氧基)苯基]乙烯基}-N-甲基苯胺([F]FBB)检测到的淀粉样蛋白负荷之间的关系，研究对象为一组阿尔茨海默病(AD)患者。
我们检查了 38 名根据 NINCDS-ADRDA 标准新诊断为 AD 的患者。所有患者均在 1 个月内平均接受了[F]FDG 和[F]FBB 的 PET/CT 扫描。我们使用 Matlab R2012b 中的统计参数映射(SPM8)和 WFU pickatlas 为包括整个皮质在内的感兴趣区(ROI)掩模定义。这些数据随后在小脑计数上进行归一化，然后在 SPM 中对[F]FDG 扫描进行回归分析。此外，还使用 58 名对照组作为[F]FDG PET/CT 扫描的对照组。
AD 患者的 SPM 分析显示，[F]FBB 与双侧颞叶和顶叶的[F]FDG 摄取之间存在显著负相关。值得注意的是，与对照组相比，AD 患者这些区域表现出明显的葡萄糖代谢低下。
[F]FBB 和[F]FDG 的联合成像显示，大脑中的淀粉样蛋白负荷与 AD 患者颞叶和顶叶皮质功能障碍有关。
