Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Acta Ophthalmol. 2018 Nov;96(7):719-723. doi: 10.1111/aos.13664. Epub 2018 Feb 6.
Idiopathic intracranial hypertension (IIH) is characterized by raised intracranial pressure (ICP), normal cerebrospinal composition and exclusion of alternative causes to increased ICP. The aim of this study was to evaluate long-term visual outcome in a Danish population of IIH patients.
Retrospective chart review of 41 women diagnosed with IIH between June 2007 and March 2013. Best-corrected visual acuity (BCVA), colour vision, grade and type of visual field (VF) defects and grade of papilloedema according to the Modified Frisén Score were recorded at baseline visit (V0), 2-6 months (V1) and 13 months follow-up visit (V2) from time of diagnosis.
Best-corrected visual acuity (BCVA) was reduced in 25% of eyes at V0, in 10% at V1 and in 15% at V2. Colour vision was barely affected. Visual field (VF) was affected (>grade 0) in 87% of eyes at V0 and VF defect grade significantly improved by 0.58 at V1 (p-value <0.0001) and by 0.55 at V2 (p-value <0.001). The most common type of VF defect at V0 was a nerve fibre layer defect (56.4%), and the second most common type was an enlarged blind spot (20.5%). There was no correlation between BCVA and VF defect type. Mean grade of papilloedema decreased from 2.2 at V0 to 0.5 at V2. The grade of papilloedema at V2 was not significantly related to the severity of papilloedema at V0 (p-values 0.65 and 0.48).
Idiopathic intracranial hypertension (IIH) is associated with long-term loss of visual function, and relevant treatment strategies need to be improved.
特发性颅内高压（IIH）的特征是颅内压升高（ICP）、脑脊液成分正常和排除导致 ICP 升高的其他原因。本研究旨在评估丹麦 IIH 患者人群的长期视力结果。
回顾性分析 2007 年 6 月至 2013 年 3 月期间诊断为 IIH 的 41 名女性患者的病历。在基线访视（V0）、诊断后 2-6 个月（V1）和 13 个月随访访视（V2）时记录最佳矫正视力（BCVA）、色觉、视野（VF）缺损的程度和类型以及改良 Frisén 评分的视盘水肿程度。
在 V0 时，25%的眼睛的 BCVA 降低，在 V1 时 10%的眼睛的 BCVA 降低，在 V2 时 15%的眼睛的 BCVA 降低。色觉几乎不受影响。在 V0 和 VF 缺损程度在 V1 时显著改善 0.58（p 值<0.0001）和 V2 时改善 0.55（p 值<0.001）。在 V0 时最常见的 VF 缺损类型是神经纤维层缺损（56.4%），其次常见的是扩大的盲点（20.5%）。BCVA 与 VF 缺损类型之间无相关性。视盘水肿的平均程度从 V0 的 2.2 级下降到 V2 的 0.5 级。V2 时的视盘水肿程度与 V0 时视盘水肿的严重程度无显著相关性（p 值分别为 0.65 和 0.48）。
特发性颅内高压（IIH）与长期视觉功能丧失有关，需要改进相关治疗策略。
