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社会经济地位与前额叶皮质内区域脑血流的年龄相关性差异。

Socioeconomic Position and Age-Related Disparities in Regional Cerebral Blood Flow Within the Prefrontal Cortex.

机构信息

From the USC Suzanne Dworak-Peck School of Social Work (Hackman), University of Southern California, Los Angeles, California; and Department of Psychology (Kuan, Manuck, Gianaros), Center for the Neural Basis of Cognition (Gianaros), University of Pittsburgh, Pittsburgh, Pennsylvania.

出版信息

Psychosom Med. 2018 May;80(4):336-344. doi: 10.1097/PSY.0000000000000566.

DOI:10.1097/PSY.0000000000000566
PMID:29406324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7104768/
Abstract

OBJECTIVE

Socioeconomic position (SEP) is associated with cerebrovascular health and brain function, particularly in prefrontal cortex and medial temporal lobe regions that exhibit plasticity across the life course. However, it is unknown whether SEP associates with resting cerebral blood flow (CBF), an indicator of baseline brain function, in these regions in midlife, and whether the association is (a) period specific, with independent associations for childhood and adulthood SEP, or driven by life course SEP, and (b) explained by a persistent disparity, widening disparity, or the leveling of disparities with age.

METHODS

To address these questions, we analyzed cerebral perfusion derived by magnetic resonance imaging in a cross-sectional study of healthy adults (N = 443) who reported on childhood and adult SEP. Main effects were examined as an index of persistent disparity and age by SEP interactions as reflecting widening or leveling disparities.

RESULTS

Stable high SEP across the lifespan was associated with higher global CBF and regional CBF (rCBF) in inferior frontal gyrus. However, childhood SEP was associated with rCBF in middle frontal gyrus, as moderated by age (β = 0.04, p = .035): rCBF was inversely associated with age only for those whose parents had a high school education or below. No associations were observed for the hippocampus or amygdala.

CONCLUSIONS

Life course SEP associations with rCBF in prefrontal cortex are suggestive of persistent disparities, whereas the age by childhood SEP interaction suggests that childhood disadvantage relates to a widening disparity, independent of global differences. These differential patterns in midlife may relate to disparities in later-life cerebrovascular and neurocognitive outcomes.

摘要

目的

社会经济地位(SEP)与脑血管健康和大脑功能相关,尤其是在大脑前额叶皮层和内侧颞叶等具有终生可塑性的区域。然而,目前尚不清楚 SEP 是否与静息脑血流(CBF)相关,后者是大脑功能的基线指标,以及这种相关性是否(a)具有时期特异性,即童年和成年时期的 SEP 分别具有独立性,或者受整个生命周期的 SEP 影响,以及(b)是否由持续的、扩大的或缩小的差异来解释。

方法

为了解决这些问题,我们对健康成年人(N=443)进行了一项横断面研究,他们报告了童年和成年时期的 SEP,并通过磁共振成像分析了大脑灌注情况。主要效应被视为持久差异的指标,而 SEP 之间的相互作用则反映了差异的扩大或缩小。

结果

整个生命周期中稳定的高 SEP 与下额前回的全局 CBF 和局部 CBF(rCBF)较高有关。然而,童年时期的 SEP 与中额前回的 rCBF 有关,且受年龄的调节(β=0.04,p=0.035):仅对于那些父母受过高中或以下教育的人来说,rCBF 与年龄呈负相关。在海马体或杏仁核中未观察到相关性。

结论

生命历程 SEP 与前额叶皮层 rCBF 的相关性表明存在持续的差异,而童年时期 SEP 与年龄的相互作用表明,童年时期的劣势与扩大的差异有关,与全球差异无关。这些差异模式可能与中老年时期的脑血管和神经认知结果的差异有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1160/7104768/731a72d37fc2/nihms-1557714-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1160/7104768/731a72d37fc2/nihms-1557714-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1160/7104768/731a72d37fc2/nihms-1557714-f0001.jpg

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本文引用的文献

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Am J Physiol Heart Circ Physiol. 2018 Jun 1;314(6):H1117-H1136. doi: 10.1152/ajpheart.00535.2017. Epub 2018 Feb 2.
2
Functional brain organization of working memory in adolescents varies in relation to family income and academic achievement.青少年工作记忆的大脑功能组织与家庭收入和学业成绩有关。
Dev Sci. 2017 Sep;20(5). doi: 10.1111/desc.12450. Epub 2016 Jul 19.
3
Life-Course Socioeconomic Position and Hippocampal Atrophy in a Prospective Cohort of Older Adults.老年人群前瞻性队列研究中的生命历程社会经济地位与海马萎缩
Psychosom Med. 2017 Jan;79(1):14-23. doi: 10.1097/PSY.0000000000000365.
4
Effect of Hippocampal and Amygdala Connectivity on the Relationship Between Preschool Poverty and School-Age Depression.海马体与杏仁核连通性对学前贫困与学龄期抑郁之间关系的影响。
Am J Psychiatry. 2016 Jun 1;173(6):625-34. doi: 10.1176/appi.ajp.2015.15081014. Epub 2016 Jan 15.
5
Community Socioeconomic Disadvantage in Midlife Relates to Cortical Morphology via Neuroendocrine and Cardiometabolic Pathways.中年时期的社区社会经济劣势通过神经内分泌和心脏代谢途径与皮质形态相关。
Cereb Cortex. 2017 Jan 1;27(1):460-473. doi: 10.1093/cercor/bhv233.
6
Comparison of Regional Brain Perfusion Levels in Chronically Smoking and Non-Smoking Adults.长期吸烟与不吸烟成年人脑区灌注水平的比较。
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7
Childhood Poverty Predicts Adult Amygdala and Frontal Activity and Connectivity in Response to Emotional Faces.童年贫困预示着成年人在面对情绪面孔时杏仁核和额叶的活动及连接情况。
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8
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Childhood adversity and neural development: deprivation and threat as distinct dimensions of early experience.童年逆境与神经发育:剥夺和威胁作为早期经历的不同维度。
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10
Socioeconomic status and structural brain development.社会经济地位与大脑结构发育。
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