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Protecting Donor Livers During Normothermic Machine Perfusion With Stem Cell Extracellular Vesicles.

作者信息

Sharma Ashish K, Laubach Victor E

机构信息

Department of Surgery, University of Virginia, Charlottesville, VA.

出版信息

Transplantation. 2018 May;102(5):725-726. doi: 10.1097/TP.0000000000002124.

DOI:10.1097/TP.0000000000002124
PMID:29406445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5930115/
Abstract
摘要

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Human liver stem cell-derived extracellular vesicles reduce injury in a model of normothermic machine perfusion of rat livers previously exposed to a prolonged warm ischemia.人肝干细胞来源的细胞外囊泡减少了先前经历长时间热缺血的大鼠肝脏在常温机器灌注模型中的损伤。
Transpl Int. 2021 Sep;34(9):1607-1617. doi: 10.1111/tri.13980.
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Ex Vivo Mesenchymal Stem Cell Therapy to Regenerate Machine Perfused Organs.体外间充质干细胞疗法用于再生机器灌注器官。
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本文引用的文献

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Extracellular Vesicles from Human Liver Stem Cells Reduce Injury in an Ex Vivo Normothermic Hypoxic Rat Liver Perfusion Model.人肝干细胞来源的细胞外囊泡减轻离体常温缺氧大鼠肝脏灌流模型中的损伤。
Transplantation. 2018 May;102(5):e205-e210. doi: 10.1097/TP.0000000000002123.
2
Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death.间充质基质细胞衍生的细胞外囊泡可减轻肺缺血再灌注损伤，并增强循环死亡供体肺的再灌注。
Respir Res. 2017 Dec 21;18(1):212. doi: 10.1186/s12931-017-0704-9.
3
Clinical trials using mesenchymal stem cells in liver diseases and inflammatory bowel diseases.使用间充质干细胞治疗肝脏疾病和炎症性肠病的临床试验。
Inflamm Regen. 2017 Jul 3;37:16. doi: 10.1186/s41232-017-0045-6. eCollection 2017.
4
Mesenchymal Stromal Cell Therapy for Solid Organ Transplantation.间质基质细胞治疗实体器官移植。
Transplantation. 2018 Jan;102(1):35-43. doi: 10.1097/TP.0000000000001879.
5
Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents.间充质干/基质细胞衍生的细胞外囊泡及其作为新型免疫调节治疗剂的潜力。
Int J Mol Sci. 2017 Jul 6;18(7):1450. doi: 10.3390/ijms18071450.
6
Exosomes: From Cell Debris to Potential Biomarkers in Transplantation.外泌体：从细胞碎片到移植中的潜在生物标志物
Transplantation. 2017 Oct;101(10):2275-2276. doi: 10.1097/TP.0000000000001856.
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Perfusion of isolated rat kidney with Mesenchymal Stromal Cells/Extracellular Vesicles prevents ischaemic injury.间质基质细胞/细胞外囊泡灌注分离的大鼠肾脏可预防缺血性损伤。
J Cell Mol Med. 2017 Dec;21(12):3381-3393. doi: 10.1111/jcmm.13249. Epub 2017 Jun 21.
8
Plasma Exosomes From HLA-Sensitized Kidney Transplant Recipients Contain mRNA Transcripts Which Predict Development of Antibody-Mediated Rejection.来自HLA致敏肾移植受者的血浆外泌体含有可预测抗体介导排斥反应发生的mRNA转录本。
Transplantation. 2017 Oct;101(10):2419-2428. doi: 10.1097/TP.0000000000001834.
9
Normothermic ex-situ liver preservation: the new gold standard.常温离体肝脏保存：新的金标准。
Curr Opin Organ Transplant. 2017 Jun;22(3):274-280. doi: 10.1097/MOT.0000000000000414.
10
Activation of Fibrinolysis, But Not Coagulation, During End-Ischemic Ex Situ Normothermic Machine Perfusion of Human Donor Livers.人供体肝脏离体缺血后常温机器灌注期间纤溶而非凝血的激活
Transplantation. 2017 Feb;101(2):e42-e48. doi: 10.1097/TP.0000000000001562.