人体骨骼肌中不含可检测到的胍基乙酸。
Human skeletal muscle contains no detectable guanidinoacetic acid.
机构信息
a Applied Bioenergetics Laboratory, Faculty of Sport and Physical Education, University of Novi Sad, Novi Sad 21000, Serbia.
b University of Belgrade School of Medicine, 11000 Belgrade, Serbia.
出版信息
Appl Physiol Nutr Metab. 2018 Jun;43(6):647-649. doi: 10.1139/apnm-2017-0873. Epub 2018 Feb 6.
We analyzed data from previously completed trials to determine the effects of supplemental guanidinoacetic acid (GAA) on markers of muscle bioenergetics in healthy men using 1.5 T magnetic resonance spectroscopy. No detectable GAA (<0.1 μmol/L) was found in the vastus medialis muscle at baseline nor at follow-up. This implies deficient GAA availability in the human skeletal muscle, suggesting absent or negligible potential for creatine synthesis from GAA inside this tissue, even after GAA loading.
我们分析了先前完成的试验数据，使用 1.5T 磁共振波谱法确定了补充胍基乙酸（GAA）对健康男性肌肉生物能量学标志物的影响。在基线和随访时，股直肌中均未检测到可检测的 GAA（<0.1 μmol/L）。这意味着人体骨骼肌中 GAA 供应不足，表明即使在 GAA 负荷后，该组织中也不存在或几乎不存在从 GAA 合成肌酸的潜力。
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