Ostojic Sergej M
Biomedical Sciences Department, Faculty of Sport and Physical Education, University of Novi Sad, Lovcenska 16, 21000, Novi Sad, Serbia.
University of Belgrade School of Medicine, Belgrade, Serbia.
Eur J Nutr. 2015 Dec;54(8):1211-5. doi: 10.1007/s00394-015-1050-7. Epub 2015 Sep 28.
Dietary guanidinoacetic acid (GAA) seems to improve cellular bioenergetics by stimulating creatine biosynthesis. However, GAA could have other biological functions that might affect its possible use as a food ingredient in human nutrition. In this paper, we identified several alternative physiological roles of supplemental GAA, including the stimulation of hormonal release and neuromodulation, an alteration of metabolic utilization of arginine, and an adjustment of oxidant-antioxidant status. A better knowledge of how GAA affects human physiology may facilitate its use as an experimental nutritional intervention for novel purposes and conditions.
膳食胍基乙酸（GAA）似乎通过刺激肌酸生物合成来改善细胞生物能量学。然而，GAA可能具有其他生物学功能，这可能会影响其作为人类营养食品成分的潜在用途。在本文中，我们确定了补充GAA的几种其他生理作用，包括刺激激素释放和神经调节、改变精氨酸的代谢利用以及调节氧化还原状态。更好地了解GAA如何影响人体生理机能，可能有助于将其用作针对新目的和新情况的实验性营养干预措施。
