Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy.
Multiple Sclerosis Center, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy.
J Neurol Sci. 2018 Mar 15;386:19-22. doi: 10.1016/j.jns.2018.01.011. Epub 2018 Jan 10.
Several correlations between cognitive impairment (CI), radiologic markers and cognitive reserve (CR) have been documented in MS.
To evaluate correlation between CI and brain volume (BV) considering CR as possibile mitigating factor.
195 relapsing MS patients underwent a neuropsychological assessment using BICAMS. BV was estimated using SIENAX to obtain normalized volume of brain (NBV), white matter (NWV), gray matter (NGV) and cortical gray matter (CGV). CR was estimated using a previously validated tool.
Pearson test showed a correlation between the symbol digit modality test (SDMT) score and NBV (r=0.38; p<0.000) NGV(r=0.31; p<0.000), CGV (r=0.35; p<0.000) and CRI score(r=0.42; p<0.000). Linear regression (dependent variable:SDMT) showed a relationship with CR scores (p=0.000) and NGV(p<0.000). A difference was detected between cognitive impaired and preserved patients regarding mean of NBV(p=0.002), NGV(p=0.007), CGV(p=0.002) and CR Scores (p=0.007). Anova showed a association between the presence of CI (dependent variable) and the interaction term CRIQ × CGV (p=0.004) whit adjustment for age and disability evaluated by EDSS.
Our study shows a correlation between cognition and BV, in particular gray matter volume. Cognitive reserve is also confirmed as an important element playing a role in the complex interaction to determine the cognitive functions in MS.
几项认知障碍（CI）、影像学标志物和认知储备（CR）之间的相关性已在 MS 中得到证实。
评估 CI 与脑容量（BV）之间的相关性，同时考虑 CR 作为可能的缓解因素。
195 例复发型 MS 患者接受了 BICAMS 神经心理学评估。使用 SIENAX 估计 BV，以获得脑的标准化体积（NBV）、白质（NWV）、灰质（NGV）和皮质灰质（CGV）。CR 使用先前验证的工具进行评估。
Pearson 检验显示符号数字模态测试（SDMT）评分与 NBV（r=0.38；p<0.000）、NGV（r=0.31；p<0.000）、CGV（r=0.35；p<0.000）和 CRI 评分（r=0.42；p<0.000）之间存在相关性。线性回归（因变量：SDMT）显示与 CR 评分（p=0.000）和 NGV（p<0.000）之间存在关系。在认知障碍和认知保留患者之间，NBV（p=0.002）、NGV（p=0.007）、CGV（p=0.002）和 CR 评分（p=0.007）的平均值存在差异。方差分析显示 CI（因变量）的存在与 CRIQ×CGV 的交互项之间存在关联（p=0.004），调整了年龄和 EDSS 评估的残疾。
我们的研究显示认知与 BV 之间存在相关性，特别是灰质体积。认知储备也被证实为一个重要的元素，在决定 MS 认知功能的复杂相互作用中发挥作用。
