Friberg P, Ely D L, Wåhlander H, Nilsson H, Folkow B
Acta Physiol Scand. 1986 Apr;126(4):477-84. doi: 10.1111/j.1748-1716.1986.tb07844.x.
Normotensive (WKY) and hypertensive rats (SHR) from 5 to 13-14 weeks of age were given 'low' (LNa; 0.5 mmol Na 100 g-1 food), 'control' (CNa; 5 or 12 mmol), 'high' (HNa; 50 mmol) and in SHR also 'medium low' (mLNa; 2 mmol) and 'very high' (vHNa; 120 mmol) sodium diets, to explore how such 240-fold variations in Na intake affect cardiac design. This was assessed in isolated perfused, temporarily-arrested hearts by recordings of left ventricular (LV) diastolic pressure-volume relationships (P/V), LV and RV weights, and by calculations of the ratio between LV wall thickness and internal radius (w/ri), after in vivo recordings of awake mean arterial pressure (MAP) and heart rate (HR). In WKY, where MAP was the same in all diet groups, the HNa group showed an increased w/ri due to a 20% reduction of LV diastolic volume, with signs of reduced wall compliance compared with CNa. The LNa WKY showed less marked changes in the same direction. In the SHR LNa group, where MAP was lowered about 20 mmHg, LV diastolic volume was reduced nearly 20% at a modest w/ri increase, while HNa and Cna SHR had equal MAP, LV weights, P/V and w/ri relationships. However, in vHNa SHR, where MAP was elevated about 25 mmHg, the LV showed a mainly eccentric hypertrophy with 15% increase of diastolic volume at a slight increase of w/ri. These differentiated, and in WKY and SHR partially differing structural cardiac adaptations consequent to changes in Na intake, can hardly be ascribed only to the respective pre- and afterload alterations, suggesting that also altered neuro-hormonal profiles may have contributed with 'trophic' influences.(ABSTRACT TRUNCATED AT 250 WORDS)
给5至13 - 14周龄的血压正常大鼠（WKY）和高血压大鼠（SHR）分别喂食“低”（LNa；0.5 mmol钠/100 g食物）、“对照”（CNa；5或12 mmol）、“高”（HNa；50 mmol）的钠饮食，对于SHR还喂食“中低”（mLNa；2 mmol）和“极高”（vHNa；120 mmol）的钠饮食，以探究如此240倍的钠摄入量变化如何影响心脏结构。通过记录离体灌注、暂时停跳心脏的左心室（LV）舒张期压力 - 容积关系（P/V）、左心室和右心室重量，并在记录清醒状态下的平均动脉压（MAP）和心率（HR）后计算左心室壁厚度与内径之比（w/ri）来评估这一影响。在WKY中，所有饮食组的MAP相同，HNa组由于左心室舒张期容积减少20%，w/ri增加，与CNa组相比有壁顺应性降低的迹象。LNa组的WKY在相同方向上变化不太明显。在SHR的LNa组中，MAP降低约20 mmHg，左心室舒张期容积减少近20%，w/ri适度增加，而HNa和Cna组的SHR的MAP、左心室重量、P/V和w/ri关系相等。然而，在vHNa组的SHR中，MAP升高约25 mmHg，左心室主要表现为离心性肥大，舒张期容积增加15%，w/ri略有增加。这些因钠摄入量变化而产生的不同的、在WKY和SHR中部分不同的心脏结构适应性变化，很难仅归因于各自的前负荷和后负荷改变，这表明神经 - 激素谱的改变也可能通过“营养”影响发挥了作用。（摘要截断于250字）
