Bata Bashar M, Pulido Jose S, Patel Sanjay V, Khan Shakila P, Salomao Diva, Boyce Thomas G, Bothun Erick D
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.
Department of Pediatric and Adolescent Medicine, Division of Hematology and Oncology, Mayo Clinic, Rochester, Minnesota.
J AAPOS. 2018 Apr;22(2):159-161. doi: 10.1016/j.jaapos.2017.10.016. Epub 2018 Apr 3.
Post-transplant lymphoproliferative disorder (PTLD) has rarely been associated with ocular manifestations. We report a case of bilateral ocular involvement by PTLD with histopathologic features of extranodal marginal zone (MALT) lymphoma in an 8-year-old boy following orthotopic heart transplantation. The anterior segment disease was treated successfully using a combination of intraocular and systemic injections of humanized anti-CD20 antibody (rituximab).
移植后淋巴组织增生性疾病（PTLD）很少伴有眼部表现。我们报告一例8岁男孩原位心脏移植后发生的PTLD双侧眼部受累病例，其组织病理学特征为结外边缘区（MALT）淋巴瘤。前段疾病通过眼内及全身注射人源化抗CD20抗体（利妥昔单抗）联合治疗成功治愈。
