Ashby M A, Lazarchick J
Am J Med Sci. 1986 Jul;292(1):53-5. doi: 10.1097/00000441-198607000-00011.
A 58-year-old black woman with IgD multiple myeloma developed a hemorrhagic diathesis within 48 hours after receiving mithramycin (20 micrograms/kg/day) for therapy of hypercalcemia. Her coagulation studies were characterized by prolonged prothrombin, partial thromboplastin, thrombin, and reptilase clotting times. Her plasma and partially purified fibrinogen were inhibitory to the clotting of normal plasma and fibrinogen. The patient's isolated fibrinogen showed a normal rate of fibrinopeptide release, but her fibrin monomer aggregation was markedly abnormal. These studies document the development of a dysfibrinogenemia secondary to mithramycin toxicity.
一名58岁的患有IgD型多发性骨髓瘤的黑人女性，在接受光辉霉素（20微克/千克/天）治疗高钙血症后48小时内出现了出血素质。她的凝血研究表现为凝血酶原时间、部分凝血活酶时间、凝血酶时间和爬虫酶凝血时间延长。她的血浆和部分纯化的纤维蛋白原对正常血浆和纤维蛋白原的凝血有抑制作用。患者分离出的纤维蛋白原显示纤维蛋白肽释放速率正常，但她的纤维蛋白单体聚合明显异常。这些研究证明了继发于光辉霉素毒性的异常纤维蛋白原血症的发生。
