Oral Sciences Research Group, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences; College of Dentistry, University of Baghdad, Iraq.
Oral Sciences Research Group, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences.
Nanomedicine. 2018 Apr;14(3):1045-1049. doi: 10.1016/j.nano.2018.01.011. Epub 2018 Feb 2.
Management of fungal biofilms represents a significant challenge to healthcare. As a preventive approach, minimizing adhesion between indwelling medical devices and microorganisms would be an important step forward. This study investigated the anti-fouling capacity of engineered nanoscale topographies to the pathogenic yeast Candida albicans. Highly ordered arrays of nano-pit topographies were shown to significantly reduce the physical adherence capacity of C. albicans. This study shows a potential of nanoscale patterns to inhibit and prevent pathogenic biofilm formation on biomedical substrates.
真菌生物膜的管理对医疗保健构成了重大挑战。作为一种预防方法，最大限度地减少留置医疗器械与微生物之间的黏附将是向前迈出的重要一步。本研究调查了工程纳米级形貌对致病性酵母白色念珠菌的抗污能力。研究表明，高度有序的纳米坑形貌阵列可显著降低白色念珠菌的物理附着能力。本研究表明纳米图案具有抑制和防止生物医学基材上致病性生物膜形成的潜力。
