Swedish Medical Center and University of Washington, Seattle.
Leiden University Medical Center, Leiden, The Netherlands.
Arthritis Care Res (Hoboken). 2018 Nov;70(11):1661-1670. doi: 10.1002/acr.23534. Epub 2018 Oct 8.
To describe the characteristics of patients with ankylosing spondylitis (AS) and patients with nonradiographic axial spondyloarthritis (SpA) in the US.
Demographics, clinical characteristics, patient-reported outcomes, and treatment characteristics of patients with AS and those with nonradiographic axial SpA were assessed at the time of enrollment in the Corrona Psoriatic Arthritis/Spondyloarthritis Registry. Patients with AS were defined as those who fulfilled the 1984 modified New York criteria for AS; patients with nonradiographic axial SpA were defined as all other patients with axial SpA who did not fulfill the radiology criterion.
Of the 407 patients with a diagnosis of axial SpA who were included in this study, 310 had AS, and 97 had nonradiographic axial SpA. Although patients with nonradiographic axial SpA were younger and showed a trend toward a shorter symptom duration, the nonradiographic axial SpA and AS groups shared a similar disease burden, as reflected by comparisons of disease activity and function, quality of life, pain, fatigue, job absenteeism, and loss of work productivity (all P > 0.05). The proportions of patients with nonradiographic axial SpA and patients with AS who received prior biologic disease-modifying drugs (DMARDs) (74.2% and 64.8%, respectively) or were currently receiving biologic DMARDs (63.9% and 61.3%, respectively) were also similar (P > 0.05).
This was the first nationwide study to characterize patients with AS and nonradiographic axial SpA in the US. Consistent with studies published outside of the US, this study showed that patients with nonradiographic axial SpA and patients with AS shared a comparable degree of disease burden and had similar treatment patterns in clinical practice.
描述美国强直性脊柱炎（AS）患者和非放射学中轴型脊柱关节炎（SpA）患者的特征。
在 Corrona 银屑病关节炎/脊柱关节炎登记处入组时，评估 AS 患者和非放射学中轴型 SpA 患者的人口统计学、临床特征、患者报告结局和治疗特征。AS 患者定义为符合 1984 年改良纽约 AS 标准的患者；非放射学中轴型 SpA 患者定义为所有不符合放射学标准的其他中轴型 SpA 患者。
本研究纳入的 407 例中轴型 SpA 患者中，310 例为 AS，97 例为非放射学中轴型 SpA。尽管非放射学中轴型 SpA 患者年龄较小且症状持续时间较短，但非放射学中轴型 SpA 和 AS 组的疾病负担相似，这反映在疾病活动度和功能、生活质量、疼痛、疲劳、旷工和工作生产力丧失的比较中（均 P＞0.05）。非放射学中轴型 SpA 和 AS 患者分别接受过生物疾病修正治疗（DMARDs）的比例（分别为 74.2%和 64.8%）或正在接受生物 DMARDs 的比例（分别为 63.9%和 61.3%）也相似（P＞0.05）。
这是第一项在美国描述 AS 和非放射学中轴型 SpA 患者的全国性研究。与美国以外发表的研究一致，本研究表明，非放射学中轴型 SpA 和 AS 患者的疾病负担相当，在临床实践中具有相似的治疗模式。
