Zachariae H
Acta Derm Venereol Suppl (Stockh). 1979;59(85):199-205.
The changes in disease pattern in a Danish skin clinic during the period 1947 to 1977 is reported. The data rest upon comparisons from patient registrations taken with ten years interval. The study also comprises comparison of frequencies of positive patch tests between 1947 and 1977. The data show, that the disease pattern was far from stable. An increased frequency was registered in atopic dermatitis, allergic contact dermatitis, drug eruptions, urticaria, skin cancer, psoriasis and viral diseases. While reductions were found in all other infectious diseases, seborrheic dermatitis, and so called "non classified eczema". The changes are postulated to be of a multifactorial origine. Environment was supposed to be the main factor in regard to contact dermatitis and some infections and to be of great importance to skin cancer, while better therapeutic posibilities seem to have influenced the frequency of most of the remaining disease groups. Pronounced changes were also registered among the ten most commonly detected contact allergens. It is stated that preventive measures are extremely important within this area. The decrease in contact allergy to balsam of Peru is used as an example of the effects of good preventive medicine.
本文报告了1947年至1977年期间丹麦一家皮肤诊所疾病模式的变化。数据基于每隔十年进行一次的患者登记比较。该研究还包括1947年至1977年间斑贴试验阳性频率的比较。数据显示，疾病模式远不稳定。特应性皮炎、过敏性接触性皮炎、药疹、荨麻疹、皮肤癌、银屑病和病毒性疾病的发病率有所上升。而在所有其他传染病、脂溢性皮炎以及所谓的“未分类湿疹”中则有所下降。这些变化被认为是多因素导致的。环境被认为是接触性皮炎和一些感染的主要因素，对皮肤癌也非常重要，而更好的治疗可能性似乎影响了大多数其他疾病组的发病率。在十种最常见的接触性变应原中也记录到了显著变化。据称，预防措施在该领域极为重要。以秘鲁香脂接触过敏的减少为例，说明了良好预防医学的效果。
