Department of ICU, Shanghai General Hospital, Shanghai Jiao Tong University School of medicine, No. 650 New Songjiang Road, Songjiang, Shanghai 201600, China.
Shanghai General Hospital, Shanghai Jiao Tong University School of medicine, No. 650 New Songjiang Road, Songjiang, Shanghai 201600, China.
Am J Emerg Med. 2018 Oct;36(10):1789-1795. doi: 10.1016/j.ajem.2018.01.092. Epub 2018 Mar 1.
The purpose of our study is to evaluate the efficacy of penta-therapy for HL-SAP in a retrospective study.
Retrospective study between January 2007 and December 2016 in a hospital intensive care unit. HL-SAP patients were assigned to conventional treatment alone (the control group) or conventional treatment with the experimental protocol (the penta-therapy group) consists of blood purification, antihyperlipidemic agents, low-molecular weight heparin, insulin, covering the whole abdomen with Pixiao (a traditional Chinese medicine). Serum triglyceride, serum calcium, APACHE II score, SOFA score, Ranson score, and other serum biomarkers were evaluated. The hospital length of stay, local complications, systematic complications, rate of recurrence, overall mortality, and operation rate were considered clinical outcomes.
63 HL-SAP patients received conventional treatment alone (the control group) and 25 patients underwent penta- therapy combined with conventional treatment (the penta-therapy group). Serum amylase, serum triglyceride, white blood cell count, C-reactive protein, and blood sugar were significantly reduced, while serum calcium was significantly increased with penta-therapy. The changes in serum amylase, serum calcium were significantly different between the penta-therapy and control group on 7th day after the initiation of treatment. The reduction in serum triglyceride in the penta-therapy group on the second day and 7th day were greater than the control group. Patients in the penta-therapy group had a significantly shorter length of hospital stay.
This study suggests that the addition of penta-therapy to conventional treatment for HL-SAP may be superior to conventional treatment alone for improvement of serum biomarkers and clinical outcomes.
本研究旨在通过回顾性研究评估 penta-therapy 对 HL-SAP 的疗效。
回顾性研究于 2007 年 1 月至 2016 年 12 月在医院重症监护病房进行。HL-SAP 患者被分为单独接受常规治疗（对照组）或常规治疗加实验方案（penta-therapy 组），实验方案包括血液净化、降脂药物、低分子量肝素、胰岛素、全身外敷 Pixiao（一种中药）。评估血清甘油三酯、血清钙、APACHE II 评分、SOFA 评分、Ranson 评分和其他血清生物标志物。将住院时间、局部并发症、全身并发症、复发率、总死亡率和手术率作为临床结果。
63 例 HL-SAP 患者接受单独常规治疗（对照组），25 例患者接受 penta-therapy 联合常规治疗（penta-therapy 组）。penta-therapy 可显著降低血清淀粉酶、血清甘油三酯、白细胞计数、C 反应蛋白和血糖，同时显著升高血清钙。治疗开始后第 7 天，penta-therapy 组血清淀粉酶和血清钙的变化明显不同于对照组。penta-therapy 组血清甘油三酯在第 2 天和第 7 天的降低幅度大于对照组。penta-therapy 组的住院时间明显缩短。
本研究表明，HL-SAP 患者在常规治疗的基础上联合 penta-therapy 可能优于单独常规治疗，可改善血清生物标志物和临床结局。
