Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico; Polyclinique de Dermatologie, Hôpital Régional de Lanaudière Quebec, Quebec, Canada.
Department of Dermatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran, Mexico City, Mexico.
J Am Acad Dermatol. 2018 Jun;78(6):1178-1184. doi: 10.1016/j.jaad.2018.01.031. Epub 2018 Jan 31.
The histologic findings of scalp involvement in dermatomyositis are not well characterized on account of a lack of large series.
To systematize the histologic features of scalp involvement in dermatomyositis on horizontal and vertical sections.
A descriptive, prospective, cross-sectional study recruited 31 patients with pathologically and serologically confirmed dermatomyositis in Mexico City, Mexico, from June 2014 to June 2015. A total of 36 scalp biopsy specimens from 20 patients with scalp involvement in dermatomyositis were processed as 20 vertical and 16 horizontal sections.
Dilated capillaries and diffuse mucin deposition were detected in all biopsy specimens, followed by interface dermatitis. Partial or segmental thickening of the basement membrane, hyperkeratosis, atrophic epidermis, and acrosyringeal hypergranulosis with hyperkeratosis were other very common findings. Preserved follicular architecture, with intact or slightly atrophic sebaceous glands, was present in most horizontal sections. There was decreased follicular density, with a terminal-to-vellus ratio of 4:1 and telogen count of 10.3%. Eosinophils were present in 15% and 25% of horizontal and vertical sections, respectively.
No special stains performed.
Scalp involvement in dermatomyositis shows nonscarring pattern on horizontal sections that is consistent with chronic telogen effluvium. Telangiectasia and mucin are universal histologic features; eosinophils and acrosyringeal hypergranulosis with hyperkeratosis are new findings.
由于缺乏大样本量，皮肌炎头皮受累的组织学表现尚不清楚。
对皮肌炎头皮受累的水平和垂直切片的组织学特征进行系统描述。
一项描述性、前瞻性、横断面研究于 2014 年 6 月至 2015 年 6 月在墨西哥城招募了 31 例经病理和血清学证实的皮肌炎患者。对 20 例皮肌炎头皮受累患者的 36 例头皮活检标本进行处理，制作 20 个垂直切片和 16 个水平切片。
所有活检标本均检测到扩张的毛细血管和弥漫性黏蛋白沉积，其次是界面性皮炎。部分或节段性基底膜增厚、角化过度、表皮萎缩和伴有角化过度的棘层松解性过度角化是其他非常常见的表现。大多数水平切片中保留了完整或轻微萎缩的毛囊结构，伴有完整或轻微萎缩的皮脂腺。水平和垂直切片的终毛与毳毛的比例分别为 4:1 和 10.3%。分别有 15%和 25%的水平和垂直切片中有嗜酸性粒细胞。
未行特殊染色。
皮肌炎头皮受累的水平切片表现为非瘢痕性，与慢性休止期脱发一致。毛细血管扩张和黏蛋白是普遍存在的组织学特征；嗜酸性粒细胞和伴有角化过度的棘层松解性过度角化是新的发现。
