Hvedstrup Jeppe, Radojicic Aleksandra, Moudrous Walid, Herklots Martin Willy, Wert Anton, Holzgraefe Manfred, Obermann Mark, Schoonman Guus G, Jensen Rigmor Højland, Schytz Henrik Winther
Headache Diagnostic Laboratory, Danish Headache Center and Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark.
Danish Headache Center and Department of Neurology, Rigshospitalet-Glostrup, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark; Neurology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
World Neurosurg. 2018 Apr;112:e576-e580. doi: 10.1016/j.wneu.2018.01.089. Epub 2018 Feb 2.
To compare a new method of noninvasive intracranial pressure (nICP) measurement with conventional lumbar puncture (LP) opening pressure.
In a prospective multicenter study, patients undergoing LP for diagnostic purposes underwent intracranial pressure measurements with HeadSense, a noninvasive transcranial acoustic device, and indirectly with LP. Noninvasive measurements were conducted with the head in a 30° tilt and in supine position before and after LP. The primary endpoint was the correlation between nICP measurement in supine position before LP and the LP opening pressure.
There was no correlation between supine nICPs before LP and the LP opening pressures (r = -0.211, P = 0.358). The 30° head-tilt nICPs correlated with the supine nICPs before LP (r = 0.830, P < 0.01). There was no correlation between supine nICPs before and after LP (r = 0.056, P = 0.831) or between 30° head-tilt nICPs and LP opening pressures (r = -0.038, P = 0.861).
There was no correlation between nICPs and LP opening pressures. Further development is warranted before transcranial acoustic HeadSense can become a clinical tool for investigating patients with neurologic conditions.
比较一种新的无创颅内压（nICP）测量方法与传统腰椎穿刺（LP）初压。
在一项前瞻性多中心研究中，因诊断目的接受LP的患者使用无创经颅声学设备HeadSense进行颅内压测量，并间接通过LP测量。在LP前后，分别在头部呈30°倾斜位和仰卧位进行无创测量。主要终点是LP前仰卧位nICP测量值与LP初压之间的相关性。
LP前仰卧位nICP与LP初压之间无相关性（r = -0.211，P = 0.358）。头部30°倾斜位nICP与LP前仰卧位nICP相关（r = 0.830，P < 0.01）。LP前后仰卧位nICP之间无相关性（r = 0.056，P = 0.831），头部30°倾斜位nICP与LP初压之间也无相关性（r = -0.038，P = 0.861）。
nICP与LP初压之间无相关性。在经颅声学设备HeadSense成为用于调查神经系统疾病患者的临床工具之前，有必要进一步研发。
