Microbiology Unit, Department of Botany and Plant Biology, Sciences III, University of Geneva, Geneva, Switzerland.
Microbiology Unit, Department of Botany and Plant Biology, Sciences III, University of Geneva, Geneva, Switzerland; School of Pharmaceutical Sciences, University of Geneva and University of Lausanne, Geneva, Switzerland.
Biochim Biophys Acta Gene Regul Mech. 2019 Jul;1862(7):722-733. doi: 10.1016/j.bbagrm.2018.01.018. Epub 2018 Feb 2.
Zinc is an essential trace element for almost all living organisms. In the opportunistic bacterial pathogen Pseudomonas aeruginosa, zinc has been shown to play an important role in virulence, in colonization of the host organism and has also been shown to be involved in antibiotic resistance. P. aeruginosa possesses numerous systems enabling it to thrive in zinc-depleted conditions as well as high-zinc situations, two environments that are encountered during human infection. These capabilities account for its pathogenic strength. The main aim of this review is to focus on zinc homeostasis in P. aeruginosa and the genetic regulation of the systems involved. The interconnection with virulence, as well as the mechanism of co-regulation between metal and antibiotic resistance, are of prime interest for understanding the molecular mechanisms allowing P. aeruginosa to switch from its existence as a common environmental bacterium to a severe opportunistic pathogen. This article is part of a Special Issue entitled: Dynamic gene expression, edited by Prof. Patrick Viollier.
锌是几乎所有生物体必需的微量元素。在机会性病原体铜绿假单胞菌中，锌已被证明在毒力、宿主定植中起着重要作用，并且还与抗生素耐药性有关。铜绿假单胞菌拥有众多的系统，使其能够在缺锌和高锌的环境中茁壮成长，这两种环境在人类感染过程中都会遇到。这些能力使其具有致病性。本综述的主要目的是集中讨论铜绿假单胞菌中的锌稳态和相关系统的遗传调控。锌稳态与毒力的相互关系，以及金属和抗生素耐药性之间的共调控机制，对于理解允许铜绿假单胞菌从普通环境细菌转变为严重机会性病原体的分子机制至关重要。本文是由 Patrick Viollier 教授编辑的题为“动态基因表达”的特刊的一部分。
