Shriver J W
Biochem Cell Biol. 1986 Apr;64(4):265-76. doi: 10.1139/o86-038.
The present understanding of the relationship between the structure of the myosin ATPase and its role in force production for muscle contraction is reviewed. Emphasis is placed on structural transitions in myosin that occur during ATP hydrolysis which may be correlated with force production. Although detailed structural information is presently lacking, numerous spectroscopic and kinetic experiments have indicated that myosin exists in two structural states for each chemical intermediate in the hydrolysis of ATP. Models are discussed which view a transition between these two states as the energy transduction "event" (i.e., force production).
本文综述了目前对肌球蛋白ATP酶结构与其在肌肉收缩力产生中作用之间关系的理解。重点在于肌球蛋白在ATP水解过程中发生的结构转变，这些转变可能与力的产生相关。尽管目前缺乏详细的结构信息，但大量的光谱学和动力学实验表明，对于ATP水解的每个化学中间体，肌球蛋白都存在两种结构状态。文中讨论了一些模型，这些模型将这两种状态之间的转变视为能量转换“事件”（即力的产生）。
