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Tetracaine derivatives for catecholaminergic polymorphic ventricular tachycardia: New drugs for correction of diastolic Ca leak?用于儿茶酚胺能多形性室性心动过速的丁卡因衍生物：纠正舒张期钙泄漏的新药？
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Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia.心肌兰尼碱受体/钙释放通道与儿茶酚胺能多形性室性心动过速的关系。
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S4153R is a gain-of-function mutation in the cardiac Ca(2+) release channel ryanodine receptor associated with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillation.S4153R 是心脏 Ca(2+)释放通道 Ryanodine 受体的功能获得性突变，与儿茶酚胺多形性室性心动过速和阵发性心房颤动有关。
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A novel variant in RyR2 causes familiar catecholaminergic polymorphic ventricular tachycardia.兰尼碱受体2（RyR2）中的一种新型变异导致家族性儿茶酚胺能多形性室性心动过速。
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Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase.心肌细胞中肌浆网钙泄漏的β-肾上腺素能增强由钙/钙调蛋白依赖性蛋白激酶介导。
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Complex atrial arrhythmias as first manifestation of catecholaminergic polymorphic ventricular tachycardia: an unusual course in a patient with a new mutation in ryanodine receptor type 2 gene.复杂性房性心律失常作为儿茶酚胺能多形性室性心动过速的首发表现：一名携带2型兰尼碱受体基因新突变患者的不寻常病程
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Catecholaminergic Polymorphic Ventricular Tachycardia.
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Calcium channel antagonism reduces exercise-induced ventricular arrhythmias in catecholaminergic polymorphic ventricular tachycardia patients with RyR2 mutations.钙通道拮抗作用可减少携带兰尼碱受体2（RyR2）突变的儿茶酚胺能多形性室性心动过速患者运动诱发的室性心律失常。
J Cardiovasc Electrophysiol. 2005 Feb;16(2):162-6. doi: 10.1046/j.1540-8167.2005.40516.x.
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Catecholaminergic polymorphic ventricular tachycardia found in an adolescent after a methylenedioxymethamphetamine and marijuana-induced cardiac arrest.青少年在亚甲二氧基甲基苯丙胺和大麻诱发心脏骤停后出现儿茶酚胺多形性室性心动过速。
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Therapeutic Approaches of Ryanodine Receptor-Associated Heart Diseases.兰尼碱受体相关心脏病的治疗方法。
Int J Mol Sci. 2022 Apr 18;23(8):4435. doi: 10.3390/ijms23084435.

本文引用的文献

1
EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2.EL20，一种有效的抗心律失常化合物，选择性地抑制钙调蛋白缺失的兰尼碱受体 2 型。
Heart Rhythm. 2018 Apr;15(4):578-586. doi: 10.1016/j.hrthm.2017.12.017. Epub 2017 Dec 14.
2
A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome.一种精准医学方法用于挽救恶性钙调蛋白病性长QT综合征的功能。
Circ Res. 2017 Jan 6;120(1):39-48. doi: 10.1161/CIRCRESAHA.116.309283. Epub 2016 Oct 20.
3
Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.心肌细胞 Z 线钙调蛋白主要与 RyR2 结合，其减少可导致心律失常，并发生于心力衰竭中。
Circ Res. 2014 Jan 17;114(2):295-306. doi: 10.1161/CIRCRESAHA.114.302857. Epub 2013 Nov 1.
4
Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death.钙调蛋白突变导致室性心动过速和心源性猝死。
Am J Hum Genet. 2012 Oct 5;91(4):703-12. doi: 10.1016/j.ajhg.2012.08.015.
5
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.卡维地洛及其新型类似物可抑制心律失常性贮备过度诱导的 Ca2+释放。
Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.
6
Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity.短篇交流：氟卡尼通过增加触发活动的阈值对儿茶酚胺多形性室性心动过速的小鼠模型发挥抗心律失常作用。
Circ Res. 2011 Jul 22;109(3):291-5. doi: 10.1161/CIRCRESAHA.111.247338. Epub 2011 Jun 16.
7
Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure.钙调蛋白与心脏兰尼碱受体解离导致心力衰竭时异常的 Ca(2+)释放。
Cardiovasc Res. 2010 Sep 1;87(4):609-17. doi: 10.1093/cvr/cvq108. Epub 2010 Apr 13.
8
Defective calmodulin binding to the cardiac ryanodine receptor plays a key role in CPVT-associated channel dysfunction.钙调蛋白与心脏兰尼碱受体的结合缺陷在 CPVT 相关通道功能障碍中起关键作用。
Biochem Biophys Res Commun. 2010 Apr 9;394(3):660-6. doi: 10.1016/j.bbrc.2010.03.046. Epub 2010 Mar 10.
9
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.氟卡尼可预防小鼠和人类的儿茶酚胺能多形性室性心动过速。
Nat Med. 2009 Apr;15(4):380-3. doi: 10.1038/nm.1942. Epub 2009 Mar 29.
10
Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts.兰尼碱受体中结构域间相互作用缺陷是衰竭心脏舒张期钙离子泄漏的关键原因。
Cardiovasc Res. 2009 Feb 15;81(3):536-45. doi: 10.1093/cvr/cvn303. Epub 2008 Nov 7.

Tetracaine derivatives for catecholaminergic polymorphic ventricular tachycardia: New drugs for correction of diastolic Ca leak?

作者信息

Valdivia Héctor H, Valdivia Carmen R

机构信息

Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Division of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

出版信息

Heart Rhythm. 2018 Apr;15(4):587-588. doi: 10.1016/j.hrthm.2018.01.022. Epub 2018 Feb 2.

DOI:10.1016/j.hrthm.2018.01.022
PMID:29410362
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5906042/
Abstract
摘要